首页|期刊导航|基因与疾病（英文）|A comprehensive proteomic analysis uncovers novel molecular subtypes of gastric signet ring cell carcinoma:Identification of potential prognostic biomarkers and therapeutic targets

A comprehensive proteomic analysis uncovers novel molecular subtypes of gastric signet ring cell carcinoma:Identification of potential prognostic biomarkers and therapeutic targets

Zhiyuan Jin Zhiyuan Xu Yian Du Xiaoqing Guan Guangzhao Pan Sichao Tian Juan Li Ruiwen Zhang Jiang-Jiang Qin Xiangdong Cheng Li Yuan Yubo Ma Zu Ye Zhao Zhang Yi Wang Can Hu Jinyun Dong Xinuo Zhang

基因与疾病（英文）2026，Vol.13Issue(1)：569-585,17.

基因与疾病（英文）2026，Vol.13Issue(1)：569-585,17.DOI:10.1016/j.gendis.2025.101717

A comprehensive proteomic analysis uncovers novel molecular subtypes of gastric signet ring cell carcinoma:Identification of potential prognostic biomarkers and therapeutic targets

Zhiyuan Jin ¹Zhiyuan Xu ²Yian Du ²Xiaoqing Guan ³Guangzhao Pan ³Sichao Tian ⁴Juan Li ³Ruiwen Zhang ⁵Jiang-Jiang Qin ²Xiangdong Cheng ²Li Yuan ²Yubo Ma ³Zu Ye ³Zhao Zhang ⁶Yi Wang ³Can Hu ³Jinyun Dong ³Xinuo Zhang³

作者信息

1. School of Life Sciences,Tianjin University,Tianjin 300000,China||Zhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou,Zhejiang 310022,China
2. Zhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou,Zhejiang 310022,China||Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer,Zhejiang Cancer Hospital,Hangzhou,Zhejiang 310022,China||Key Laboratory of Prevention,Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang Province,Hangzhou,Zhejiang 310022,China
3. Zhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou,Zhejiang 310022,China
4. Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193,China
5. Department of Pharmacological and Pharmaceutical Sciences,College of Pharmacy,University of Houston,Houston,TX 77204,USA
6. MOE Key Laboratory of Metabolism and Molecular Medicine,Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China
折叠

摘要

关键词

Drug target/Gastric signet ring cell carcinoma/Molecular subtypes/Prognostic markers/Proteomics

Key words

Drug target/Gastric signet ring cell carcinoma/Molecular subtypes/Prognostic markers/Proteomics

引用本文复制引用

Zhiyuan Jin,Zhiyuan Xu,Yian Du,Xiaoqing Guan,Guangzhao Pan,Sichao Tian,Juan Li,Ruiwen Zhang,Jiang-Jiang Qin,Xiangdong Cheng,Li Yuan,Yubo Ma,Zu Ye,Zhao Zhang,Yi Wang,Can Hu,Jinyun Dong,Xinuo Zhang..A comprehensive proteomic analysis uncovers novel molecular subtypes of gastric signet ring cell carcinoma:Identification of potential prognostic biomarkers and therapeutic targets[J].基因与疾病（英文）,2026,13(1):569-585,17.

基金项目

This work was supported by the National Key Research and Development Program of China(No.2021YFA0910100,2021YFA0910101),the Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer(China)(No.JBZX-202006),the Innovation Team and Talents Cultivation Pro-gram of the National Administration of Traditional Chinese Medicine(China)(No.ZYYCXTD-C-202208),the Medical Science and Technology Project of Zhejiang Province,China(No.WKJ-ZJ-2202,WKJ-ZJ-2104),the National Natural Science Foundation of China(No.82074245,81973634,82204828),the Natural Science Foundation of Zhejiang Province,China(No.QKHM25H3103,LHDMY22H160008),the Zhejiang Leading Innovation and Entrepreneurship Team(China)(No.2022R01006),the Pioneer R&D Program of Zhejiang,China(No.2024SDYXS0003,2023SDYXS0001),and the Program of Zhejiang Provincial TCM Sci-Tech Plan(China)(No.GZY-ZJ-KJ-24064). （No.2021YFA0910100,2021YFA0910101）

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