临床神经病学杂志2026，Vol.39Issue(2)：86-89,4.
长期使用β1受体阻滞剂对血管性痴呆患者认知功能的影响
Effects of long-term use of β1 blockers on cognitive function in patients with vascular dementia
摘要
Abstract
Objective To evaluate the impact of long-term β1 blocker use on cognitive function in patients with vascular dementia and analyze the efficacy concerning disease stage and comorbidity dependence.Methods Recruitment retrospectively included 240 cases of vascular dementia diagnosed between January 2020 and March 2025,including 120 cases in the long-term use of β1-receptor blockers(≥2 years)group(study group)and 120 cases in the control group.Baseline data(age,sex,comorbidities,medication history)and clinical dementia rating scale(CDR)and dementia rating scale(DRS)scores were collected through an electronic medical record system.Statistical comparisons were performed using t tests,χ2 tests,multivariable linear regression(with adjustments for confounding factors),and subgroup analyses(by dementia stage and hypertension stratification).Results The differences in age,gender,years of education,and underlying diseases between the study group and the control group had no statistically significant,showing good comparability.The CDR score of the study group was significantly lower than that of the control group,and the DRS total score was significantly higher than that of the control group(all P＜0.01).Multivariable analysis results showed that long-term use of β1 blockers was negatively correlated with CDR scores(β=-0.35,95%CI:-0.52--0.18,P＜0.001),while positively correlated with DRS total scores(β=12.5,95%CI:8.2-16.8,P＜0.001).Subgroup analysis results showed that among 114 patients with mild dementia(CDR=1),the CDR scores of the study group were significantly lower than those of the control group(P＜0.01);among 97 patients with moderate dementia(CDR=2),the difference in CDR scores between the two groups was not statistically significant(P=0.07);and among 29 patients with severe dementia(CDR=3),the difference in CDR scores between the two groups was also not statistically significant(P=0.85).In addition,among the 199 patients with hypertension,the CDR scores of the study group were significantly lower than those of the control group(P＜0.01).Conclusions Long-term use of β1 blockers can improve cognitive function in patients with vascular dementia,particularly in the early stages of the disease(CDR=1)and in those with hypertension,suggesting their potential as a targeted intervention.Clinicians should prioritize these populations and seize the therapeutic window.关键词
血管性痴呆/β1受体阻滞剂/风险/痴呆/高血压Key words
vascular dementia/β1 blockers/risk/dementia/hypertension分类
医药卫生引用本文复制引用
高晓红,王玉梅,李瑾..长期使用β1受体阻滞剂对血管性痴呆患者认知功能的影响[J].临床神经病学杂志,2026,39(2):86-89,4.基金项目
武威市科技计划(WW24B01SF055) （WW24B01SF055）
