昆明医科大学学报2026，Vol.47Issue(3)：1-11,11.DOI:10.12259/j.issn.2095-610X.S20260301
间充质干细胞经Treg-ILC2轴治疗变应性鼻炎的研究进展
Research Progress of Mesenchymal Stem Cells in the Treatment of Allergic Rhinitis via the Treg-ILC2 Axis
摘要
Abstract
Allergic rhinitis(AR)is a chronic airway disorder predominantly driven by type 2 inflammation,in which T helper(Th)cells,innate lymphoid cells(ILCs),and their characteristic type 2 cytokines serve as the core pathogenic mechanisms.Recent evidence highlights that the immune imbalance between regulatory T cells(Tregs)and group 2 innate lymphoid cells(ILC2s),termed as the Treg-ILC2 axis,has been recognized as a critical regulatory hub in AR pathogenesis.Mesenchymal stem cells(MSCs),characterized by potent immunomodulatory properties,can induce iTreg differentiation and suppress ILC2 hyperactivation through the secretion of soluble factors(e.g.,TGF-β,IL-10)and direct cell-to-cell contact mediated by the ICOS-ICOSL(inducible T-cell costimulator-inducible T-cell costimulator ligand)interaction.By reviewing the cross-talk mechanisms between Tregs and ILC2s,this article focuses on the research progress of MSCs in restoring immune homeostasis in AR via the Treg-ILC2 axis,aiming to provide theoretical foundations and novel insights for precise immune-targeted therapies for AR.关键词
变应性鼻炎/免疫靶向治疗/2组先天性淋巴样细胞/调节性T细胞/间充质干细胞/动物模型Key words
Allergic rhinitis/Immune-targeted therapy/Group 2 innate lymphoid cells/Regulatory T cells/Mesenchymal stem cells/Animal model分类
医药卫生引用本文复制引用
陈瑞,曹守明,吴海莺,黄浩甦,周小英,韩维悦,蒋宗城..间充质干细胞经Treg-ILC2轴治疗变应性鼻炎的研究进展[J].昆明医科大学学报,2026,47(3):1-11,11.基金项目
国家自然科学基金(82560215) （82560215）
云南省教育厅科学研究基金(2024J0228) （2024J0228）
