临床神经病学杂志2026，Vol.39Issue(2)：104-108,5.
术后Guillain-Barré综合征的临床与电生理特征分析:一项单中心回顾性研究
Clinical and electrophysiological characteristics of post-operative Guillain-Barré syndrome:a single-center retrospective study
摘要
Abstract
Objective To investigate the clinical features,electrophysiological subtypes,and prognosis of surgery-related Guillain-Barré syndrome(GBS),to improve clinical recognition and diagnostic accuracy of the disease.Methods This was a retrospective case-control study.The observation group incorporated 21 patients diagnosed with post-surgical GBS at our hospital from January 2015 to September 25.And 70 non-surgical GBS patients hospitalized during the same period and 30 healthy volunteers were collected as control.Clinical data were collected for both groups,including clinical manifestations,electrophysiological findings,CSF results,and prognostic indicators.The incidence of respiratory failure,autonomic dysfunction,muscle atrophy,and Hughes functional grading scale(HFGS)scores were compared,and electrophysiological subtypes were analyzed.Results The median onset time of GBS symptoms after surgery was 15 d.The main types of preceding surgeries included orthopedic,gastrointestinal,neurosurgical,and gynecological operation.All patients presented with respiratory muscle weakness in the distal limbs.Compared to the non-surgical GBS patients,the post-surgical GBS patients showed significantly higher rates of respiratory failure,autonomic dysfunction,muscle atrophy,and HFGS scores(all P＜0.05).Electrophysiological findings indicated that post-surgical GBS patients exhibited a significant reduction in compound muscle action potential amplitudes compared with the healthy control group(all P＜0.05),while motor nerve conduction velocity and distal latency were relatively preserved,suggesting that the predominant pathological subtype was acute motor axonal neuropathy.Conclusions Surgery may be an important non-infectious trigger for GBS.Rapidly progressive symmetrical limb weakness in post-surgical patients should raise suspicion for GBS.Early electrophysiological and CSF examinations are recommended to facilitate timely diagnosis and intervention,thereby improving patient outcomes.关键词
Guillain-Barré综合征/手术/神经电生理检查/急性运动轴索性神经病Key words
Guillain-Barré syndrome/surgery/electrophysiology/acute motor axonal neuropathy分类
医药卫生引用本文复制引用
陈慧,鲍磊,李庆节..术后Guillain-Barré综合征的临床与电生理特征分析:一项单中心回顾性研究[J].临床神经病学杂志,2026,39(2):104-108,5.基金项目
国家自然科学基金项目(82171305) （82171305）
徐州医科大学院级课题资助项目(2022ZL04) （2022ZL04）
