临床神经病学杂志2026，Vol.39Issue(2)：138-142,5.
动脉瘤性蛛网膜下腔出血患者血清长链非编码RNA肺腺癌相关转录本1水平与病情严重程度及预后的相关性研究
Correlation between serum levels of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 and disease severity as well as prognosis in patients with aneurysmal subarachnoid hemorrhage
摘要
Abstract
Objective To investigate the correlation between the expression level of long non-coding RNA(lncRNA)metastasis-associated lung adenocarcinoma transcript 1(MALAT1)in serum of patients with aneurysmal subarachnoid hemorrhage(aSAH)and the severity and prognosis of the disease.Methods A total of 118 aSAH patients who were treated in our hospital from June 2019 to March 2022 were regarded as observation objects(aSAH group).Among them,there were 67 cases of Hunt-Hess gradeⅠ-Ⅱ and 51 cases of gradeⅢ-Ⅳ.According to postoperative prognosis in 6 months,the patients were categorized into good prognosis subgroup(65 cases)and poor prognosis subgroup(53 cases).In addition,120 medical examiners during the same period were regarded as the control group.QRT-PCR method was applied to detect the expression level of serum lncRNA MALAT1.Logistic regression model was applied to analyze the risk factors for poor prognosis in patients with aSAH.Results The incidence rates of hypertension and diabetes were substantially higher in the aSAH group than those in the control group(all P＜0.05).The expression level of serum lncRNA MALAT 1 in the aSAH group(2.13±0.36)was significantly higher than that in the control group(1.05±0.15)(t=30.298,P＜0.05).The expression level of serum lncRNA MALAT1 in patients with grade Ⅲ-Ⅳ aSAH(2.41±0.32)was significantly higher than that in patients with grade Ⅰ-Ⅱ aSAH(1.92±0.28)(t=8.851,P＜0.05).The percentage of patients with hypertension,the rate of Hunt-Hess grade Ⅲ-Ⅳ,mFisher score 3-4,the proportions of patients with cerebral vasospasm and cerebral hemorrhage,and the expression level of lncRNA MALAT1 in the poor prognosis subgroup were significantly higher than those in the good prognosis subgroup(all P＜0.05).Logistic multivariate analysis results indicated Hunt-Hess gradeⅢ-Ⅳ,mFisher score 3-4,cerebral vasospasm,cerebral hemorrhage,and high level of lncRNA MALAT1 were identified as risk factors associated with poor prognosis in patients with aSAH(all P＜0.05).The area under the ROC curve of serum lncRNA MALAT1 for the diagnosis of poor prognosis in aSAH patients was 0.833(95%CI:0.753-0.895),and the optimal threshold was determined to be 2.03,achieving a sensitivity of 84.91%and a specificity of 75.38%.Conclusions The expression of lncRNA MALAT1 in the serum of patients with aSAH is significantly up-regulated.This elevated expression is closely associated with the severity of the disease and patient prognosis,suggesting its potential as an auxiliary biomarker for assessing the prognosis of aSAH.关键词
动脉瘤性蛛网膜下腔出血/血清/长链非编码RNA肺腺癌相关转录本1/预后Key words
aneurysmal subarachnoid hemorrhage/serum/long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1/prognosis分类
医药卫生引用本文复制引用
石宵涵,李敏,王瑞,郭为,刘杰,张盈,王卓欣..动脉瘤性蛛网膜下腔出血患者血清长链非编码RNA肺腺癌相关转录本1水平与病情严重程度及预后的相关性研究[J].临床神经病学杂志,2026,39(2):138-142,5.基金项目
国家自然科学基金资助项目(82371384) （82371384）
