化学试剂2026，Vol.48Issue(4)：1-11,11.DOI:10.13822/j.cnki.hxsj.2026.0023
表面增强拉曼光谱技术在中药分析中的应用
Applications of Surface-Enhanced Raman Spectroscopy in the Analysis of Traditional Chinese Medicines
摘要
Abstract
The chemical composition of traditional Chinese medicines(TCMs)is complex and is often susceptible to matrix interference.Traditional analytical methods are limited by their insufficient sensitivity,cumbersome sample preparation procedures,and high reliance on expensive equipment,which render them less suitable for the rapid screening and on-site detection of TCMs.Surface-enhanced Raman spectroscopy(SERS),based on the localized surface plasmon resonance effect of noble metal nanostructures,can significantly enhance the signals of trace molecules and provide"fingerprint"identification.It combines the advantages of high sensitivity,strong specificity,rapid and non-destructive analysis,good compatibility with aqueous systems,and easy integration into portable platforms,thereby providing a new technical approach for the quality analysis of complex TCM systems.This review systematically summarized the enhancement mechanisms,methodological features,and data processing strategies of SERS in TCM analyses,focusing on the progress in the identification,inspection,content determination,and holistic characterization of TCMs.Complementary strategies that combine SERS with chromatography,mass spectrometry,and chemometric methods were also discussed,along with their potential for quality monitoring throughout the TCM production process.With the continuous advancement of the SERS substrate preparation technology,establishment of standardized methods,and improvement of spectral databases,SERS was expected to play an increasingly important role in controlling the quality of TCMs.Further integration of this technology with process analytical technologies and artificial intelligence algorithms will provide a powerful tool for realizing whole-chain,real-time,and intelligent quality monitoring of samples ranging from herbal materials to finished preparations,thereby contributing to enhanced TCM quality and the modernization of the TCM industry.关键词
表面增强拉曼光谱/中药分析/快速检测/质量控制/质量监测Key words
surface-enhanced Raman spectroscopy/traditional Chinese medicine analysis/rapid detection/quality control/quality monitoring分类
化学化工引用本文复制引用
陈萱,欧书欣,谢亮,刘岩,章弘扬,江晅,付建军,张敏..表面增强拉曼光谱技术在中药分析中的应用[J].化学试剂,2026,48(4):1-11,11.基金项目
国家自然科学基金面上项目(81573397). （81573397）
