检验医学与临床2026，Vol.23Issue(7)：892-897,6.DOI:10.3969/j.issn.1672-9455.2026.07.005
针灸联合骨松宝颗粒治疗女性绝经后骨质疏松症的疗效及对血清骨代谢指标、IGF-1水平的影响
Effect of acupuncture and moxibustion combined with Gusongbao granule on postmenopausal osteoporosis and its effect on serum bone metabolism index and IGF-1 levels
摘要
Abstract
Objective To investigate the clinical efficacy of acupuncture combined with Gusongbao granule in the treatment of women with postmenopausal osteoporosis(PMOP)and its effect on serum bone metabo-lism indexes and insulin-like growth factor-1(IGF-1)levels.Methods A total of 105 postmenopausal women with PMOP admitted to Qidong People's Hospital from January 1,2022 to June 30,2024 were selected as the research objects,and all patients were divided into control group(52 cases)and observation group(53 cases)by random number table method.Both groups received basic treatment,and the control group was treated with Gusongbao granule in addition to basic treatment.The observation group was treated with acupuncture and moxibustion on the basis of the control group.The clinical efficacy,bone metabolism indexes[osteocalcin(BGP),β-collagen degradation products(β-CTX),alkaline phosphatase(ALP)],bone mineral density(BMD),visual analogue scale(VAS)score,IGF-1 level and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 98.11%,which was higher than 88.46%of the control group,and the difference was statistically significant(P<0.05).The levels of BGP and ALP in the two groups after treatment were higher than those before treatment,and the levels of BGP and ALP in the observation group after treatment were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of β-CTX in the two groups were lower than those before treatment,and the level of β-CTX in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).The BMD of L1-4 and femoral neck of the two groups after treatment were higher than those before treatment,and the BMD of L1-4 and femoral neck of the observation group after treatment were higher than those of the control group,and the differences were statistically significant(P<0.05).The VAS scores of the two groups after treatment were lower than those before treatment,and the VAS score of the observation group after treatment was lower than that of the con-trol group,and the differences were statistically significant(P<0.05).The IGF-1 levels of the two groups af-ter treatment were higher than those before treatment,and the IGF-1 level of the observation group after treatment was higher than that of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Acupuncture combined with Gusongbao granule is effective in the treatment of fe-male PMOP after menopause,which can significantly regulate bone metabolism,increase bone mineral densi-ty,relieve pain and improve serum IGF-1 level,and has good safety.关键词
绝经后骨质疏松症/骨松宝颗粒/针灸/β-胶原降解产物/胰岛素样生长因子-1Key words
postmenopausal osteoporosis/Gusongbao granule/acupuncture/β-collagen degradation products/insulin-like growth factor-1分类
医药卫生引用本文复制引用
周金芳,顾欣欣,黄凌慧,田雪峰..针灸联合骨松宝颗粒治疗女性绝经后骨质疏松症的疗效及对血清骨代谢指标、IGF-1水平的影响[J].检验医学与临床,2026,23(7):892-897,6.基金项目
江苏省南通市自然科学基金和社会民生科技计划(指导性)项目(MSZ2023063) （指导性）
江苏省启东市社会民生科技计划项目(2023-07). （2023-07）
