检验医学与临床2026，Vol.23Issue(7)：917-922,6.DOI:10.3969/j.issn.1672-9455.2026.07.009
补阳还五汤联合瑞舒伐他汀治疗急性脑梗死的临床疗效及对神经因子、脑血流动力学指标的影响
Clinical efficacy of Buyang Huanwu decoction combined with rosuvastatin in the treatment of acute cerebral infarction and its effect on neurological factor and cerebral hemodynamics
摘要
Abstract
Objective To investigate the clinical efficacy of Buyang Huanwu decoction combined with rosu-vastatin in the treatment of acute cerebral infarction(ACI)and its effect on neurological factor and cerebral hemodynamic indexes.Methods A total of 100 patients with ACI admitted to Baoding Hospital of Guang'an-men Hospital from January 2022 to March 2024 were selected as the research objects,and they were divided into the conventional group(52 cases)and the combined group(48 cases)according to the different treatment plan.The conventional group was treated with rosuvastatin,and the combined group was treated with Buyang Huanwu decoction on the basis of the conventional group.The clinical efficacy of the two groups was com-pared.The neurological factors[nerve growth factor(NGF),neuron-specific enolase(NSE),brain-derived neurotrophic factor(BDNF)],cerebral hemodynamic indexes[cerebral blood volume(CBV),cerebral blood flow(CBF),and mean transit time(MTT)],and TCM syndromes(Speech Jian astringent or no language,partial body numbness,dizziness)and total score,National Institutes of Health Stroke Scale(NIHSS)score and Barthel index scorebefore and after treatment were compared between the two groups.Results The total effective rate of the combined group was 91.67%,which was higher than 76.92%of the conventional group,and the difference was statistically significant(P<0.05).After treatment,the Barthel index score,CBF,CBV,NGF,BDNF levels of the two groups were higher than those before treatment,and the Barthel index score,CBF,CBV,NGF,BDNF levels of the combined group were higher than those of the conventional group,and the differences were statistically significant(P<0.05).After treatment,the TCM syndrome score and to-tal score,NIHSS score and NSE level of the two groups were lower than those before treatment,MTT was shorter than that before treatment,and the TCM syndrome score and total score,NIHSS score and NSE level of the combined group were lower than those of the conventional group after treatment.MTT was shorter than that of the conventional group,and the differences were statistically significant(P<0.05).Conclusion The clinical efficacy of Buyang Huanwu decoction combined with rosuvastatin in the treatment of ACI is better than that of rosuvastatin alone,and it can more effectively improve the neurological deficit,daily living ability and cerebral blood perfusion of patients.关键词
补阳还五汤/瑞舒伐他汀/急性脑梗死/脑血流动力学指标/神经功能/临床疗效Key words
Buyang Huanwu decoction/rosuvastatin/acute cerebral infarction/cerebral hemody-namic index/neurological function/clinical efficacy分类
医药卫生引用本文复制引用
王延惠,张茜,刘泽芳,翟晓莹,李卫娜,魏萌萌..补阳还五汤联合瑞舒伐他汀治疗急性脑梗死的临床疗效及对神经因子、脑血流动力学指标的影响[J].检验医学与临床,2026,23(7):917-922,6.基金项目
河北省保定市科技计划项目(2241ZF200). （2241ZF200）
