现代畜牧兽医Issue(3)：6-10,5.DOI:10.20154/j.cnki.issn1672-9692.2026.03.002
非洲猪瘟病毒A104R蛋白的结构预测及抗原表位分析
Structural prediction and epitope analysis of the A104R protein of African swine fever virus
吴丹丹1
作者信息
- 1. 湖南农业大学动物医学院,湖南 长沙 410128||兽用蛋白质工程疫苗湖南省重点实验室,湖南 长沙 410128
- 折叠
摘要
Abstract
The study aims to reveal the molecular characteristics of the A104R protein of the African swine fever virus(ASFV),providing a reference for the development of a new candidate vaccine for African swine fever(ASF).The experiment conducted a systematic analysis of the structure,conservation,and antigenic epitopes of the ASFV A104R protein using multiple online bioinformatics software.The results showed that the ASFV A104R protein consists of 104 amino acids,has 10 phosphorylation modification sites,is an alkaline protein,and has hydrophilic stability.The secondary structure of the ASFV A104R protein is dominated by the random coil region.A total of 5 B-cell dominant antigenic epitopes were identified,and they are highly conserved in different ASFV isolates.The study demonstrated that the experiment successfully conducted structural prediction and antigenic epitope analysis of the ASFV A104R protein,providing certain references for in-depth research on the biological characteristics of the main antigen proteins of ASFV and the development of new vaccines.关键词
非洲猪瘟病毒/A104R蛋白/生物信息学分析/B细胞表位预测Key words
African swine fever virus/A104R protein/Bioinformatics analysis/B-cell epitope prediction分类
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吴丹丹..非洲猪瘟病毒A104R蛋白的结构预测及抗原表位分析[J].现代畜牧兽医,2026,(3):6-10,5.
