现代畜牧兽医Issue(3)：16-20,5.DOI:10.20154/j.cnki.issn1672-9692.2026.03.004
四黄止痢纳米乳鸡口服给药途径的药代动力学特征
Pharmacokinetic characteristics of the oral administration route of Sihuang Zhili nanoemulsion in chickens
摘要
Abstract
The study aimed to determine the main components absorbed by chickens after oral administration of the Sihuang Zhili nanoemulsion and their pharmacokinetic characteristics.Adult Zhuanghe Dagu chickens were intragastrically administered 600 mg/kg of the Sihuang Zhili nanoemulsion.The main active components of the Sihuang Zhili nanoemulsion in chicken plasma were determined and detected using high-performance liquid chromatography(HPLC),and the pharmacokinetic characteristics of the drug components were analyzed and detected using DAS 2.0 software.The results showed that the main active components of the Sihuang Zhili nanoemulsion in the plasma of Zhuanghe Dagu chickens were baicalin and emodin,and they exhibited a first-order absorption two-compartment model in the chicken body.The main pharmacokinetic parameters of baicalin in the chicken body were:The total area under the plasma concentration-time(C-T)curve(AUC0-∞)was 527.37 mg/(L·h),the terminal elimination half-life(t1/2β)was 6.62 h,the first peak time(T1max)was 2.00 h,the second peak time(T2max)was 8.00 hours,the first peak concentration(C1max)was 73.44 mg/L,and the second peak concentration(C2max)was 30.46 mg/L.The main pharmacokinetic parameters of emodin in the chicken body were:AUC0-∞ was 499.23 mg/(L·h),t1/2β was 5.75 h,T1max was 3.00 h,T2max was 8.00 h,C1max was 56.88 mg/L,and C2max was 34.08 mg/L.The study demonstrated that the main active components in the plasma of Zhuanghe Dagu chickens after oral administration of the Sihuang Zhili nanoemulsion were baicalin and emodin,and both exhibited rapid peak formation and rapid clearance pharmacokinetic characteristics in the chicken body.关键词
四黄止痢纳米乳/口服/药代动力学特征/庄河大骨鸡/黄芩苷/大黄素Key words
Sihuang Zhili nanoemulsion/Oral administration/Pharmacokinetic characteristics/Zhuanghe Dagu chicken/Baicalin/Emodin分类
农业科技引用本文复制引用
刘文洋,刘莉莉,王宁,吴振远,崔苗苗,毕聪明,王宏军,蒋红..四黄止痢纳米乳鸡口服给药途径的药代动力学特征[J].现代畜牧兽医,2026,(3):16-20,5.基金项目
辽宁省科技厅博士启动项目(2023-BSBA-160) （2023-BSBA-160）
辽宁省教育厅基本科研项目(LJ212410160090) （LJ212410160090）
辽宁省凌海市禽病防控科技特派团项目(2025JH5/10400038) （2025JH5/10400038）
锦州医科大学兽医高峰学科建设项目子课题(JY20238704、JY20238705) （JY20238704、JY20238705）
