青岛大学学报（医学版）2026，Vol.62Issue(1)：135-139,5.DOI:10.11712/jms.2096-5532.2026.62.019
艾滋病男性IL-10和TGF-β1表达及其预测预后价值
Expression of interleukin-10 and transforming growth factor-beta 1 in male AIDS patients and their value in predicting prognosis
摘要
Abstract
Objective To investigate the expression levels of serum interleukin-10(IL-10)and transforming growth factor-beta 1(TGF-β1)in male AIDS patients and their value in predicting prognosis.Methods A total of 46 male AIDS patients who were admitted to Nanchong Central Hospital from April 2021 to February 2024 were enrolled as observation group,and 55 male in-dividuals of the same age who underwent physical examination during the same period of time were enrolled as control group.Ac-cording to the follow-up results at 6 months,the observation group was further divided into good prognosis group with 28 patients and poor prognosis group with 18 patients,and the general data were compared between the two groups.The expression levels of serum IL-10 and TGF-β1 were measured for all subjects after admission and then were compared between groups.A multivariate logistic regression analysis was used to investigate the influencing factors for the prognosis of male AIDS patients,and the receiver operating characteristic(ROC)curve and the area under the ROC curve(AUC)were used to assess the value of the expression le-vels of serum IL-10 and TGF-β1 in predicting the prognosis of male AIDS patients.Results The observation group had signifi-cantly higher expression levels of serum IL-10 and TGF-β1 than the control group(t=22.286,25.053;both P＜0.05),and the poor prognosis group had significantly higher expression levels of serum IL-10 and TGF-β1 than the good prognosis group(t=12.035,14.472;both P＜0.05).The multivariate logistic regression analysis showed that the expression levels of serum IL-10(OR=3.762,95％CI=2.065-6.854,P＜0.05)and TGF-β1(OR=4.577,95％CI=2.238-9.360,P＜0.05)were both risk factors for poor prognosis in male AIDS patients.The ROC curve analysis showed that serum IL-10 and TGF-β1 used alone and in combi-nation had an AUC of 0.844,0.851,and 0.905(95％CI=0.794-0.855 to 0.894-0.955,allP＜0.05),respectively,in predicting poor prognosis in male AIDS patients,and the combination of the two indicators had the highest predictive value.Conclusion There are significant increases in the expression levels of serum IL-10 and TGF-β1 in male AIDS patients,and the expression levels of serum IL-10 and TGF-β1 are closely associated with prognosis.Combined measurement of the two indicators has a high value in pre-dicting poor prognosis.关键词
获得性免疫缺陷综合征/男(雄)性/白细胞介素10/转化生长因子β1/预后/预测Key words
acquired immunodeficiency syndrome/male/inter-leukin-10/transforming growth factor beta 1/prognosis/forecasting分类
医药卫生引用本文复制引用
张昌艳,陈智慧,何蓉会,李双良..艾滋病男性IL-10和TGF-β1表达及其预测预后价值[J].青岛大学学报（医学版）,2026,62(1):135-139,5.基金项目
四川省基层卫生事业发展研究中心项目(SWFZ22-Y-17) （SWFZ22-Y-17）
