检验医学与临床2026，Vol.23Issue(7)：996-1001,1008,7.DOI:10.3969/j.issn.1672-9455.2026.07.021
脑小血管病患者血清S100B、SD-LDL水平与LOTCA评分的相关性及对认知功能障碍的预测价值
Correlations between serum S100B and SD-LDL levels and LOTCA scores and their predictive value for cognitive impairment in patients with cerebral small vessel disease
摘要
Abstract
Objective To investigate the correlation between serum levels of central nervous system specif-ic protein(S100B)and Small Dense Low-Density Lipoprotein(SD-LDL)and Loewenstein Occupational Ther-apy Cognitive Assessment(LOTCA)scores in patients with Cerebral Small Vessel Disease(CSVD)and their predictive value for cognitive impairment(CI).Methods A total of 148 CSVD patients admitted to the Sec-ond Affiliated Hospital of Xingtai Medical University from September 2023 to January 2025 were selected as the research objects.The CSVD patients with CI were selected as the observation group,and the CSVD pa-tients without CI were selected as the control group.Enzyme-linked immunosorbent assay was used to detect the serum levels of S100B and SD-LDL in all subjects.Spearman correlation analysis was used to analyze the correlation between serum S100B,SD-LDL levels and LOTCA scores in CSVD patients with CI.Multivariate Logistic regression was used to analyze the influencing factors of CI in CSVD patients.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum S100B,SD-LDL alone and their combination for CI in CSVD patients.Results The severity of white matter hyperintensities(moderate and severe)and the levels of serum high-sensitivity C-reactive protein(hs-CRP),homocysteine(Hcy),lipoprotein associated phospholipase A2(Lp-PLA2),S100B and SD-LDL in the observation group were significantly high-er than those in the control group,and the LOTCA scores in each dimension were significantly lower than those in the control group,the differences were statistically significant(P<0.05).Spearman correlation anal-ysis showed that the levels of serum S100B and SD-LDL in CSVD patients with CI were negatively correlated with the scores of each dimension of LOTCA(P<0.05).Multivariate Logistic regression analysis showed that the severity of white matter hyperintensities(moderate and severe)and the increased levels of serum hs-CRP,Hcy,Lp-PLA2,S100B and SD-LDL were all risk factors for CI in CSVD patients(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum S100B,SD-LDL and their combination for pre-dicting CI in CSVD patients were 0.841,0.803 and 0.925,respectively.The AUC of the combination of S100B and SD-LDL in predicting CI in CSVD patients was greater than that of serum S100B or SD-LDL alone(Z=3.352,3.527,P<0.05).Conclusion The levels of serum S100B and SD-LDL in CSVD patients are in-creased,and negatively correlated with LOTCA scores.The combined detection of S100B and SD-LDL has a high predictive value for CI in CSVD patients.关键词
脑小血管病/中枢神经特异性蛋白/小而密-低密度脂蛋白/洛文斯顿作业疗法认知评定量表评分/认知功能障碍Key words
cerebral small vessel disease/central nervous system specific protein/small dense low-density lipoprotein/Loewenstein Occupational Therapy Cognitive Assessment score/cognitive dysfunction分类
医药卫生引用本文复制引用
杨利革,马冠峰,刘艺丽..脑小血管病患者血清S100B、SD-LDL水平与LOTCA评分的相关性及对认知功能障碍的预测价值[J].检验医学与临床,2026,23(7):996-1001,1008,7.基金项目
河北省医学科学研究课题(20251423). （20251423）
