皮肤性病诊疗学杂志2026，Vol.33Issue(3)：186-192,7.DOI:10.3969/j.issn.1674-8468.2026.03.004
微型环钻切除术联合CO2点阵激光治疗萎缩性痤疮瘢痕的疗效与安全性评估
Evaluation of the efficacy and safety of micro-punch excision combined with CO2 fractional laser in the treatment of atrophic acne scars
摘要
Abstract
Objective To evaluate the efficacy and safety of micro-punch excision combined with CO2 fractional laser treatment for facial atrophic acne scars,and to compare it with CO2 frac-tional laser therapy alone.Methods From September 2023 to September 2024,70 patients with facial atrophic acne scars admitted to the Department of Dermatology at the Third Affiliated Hospi-tal of Henan Medical University were randomly divided into an experimental group and a control group,with 35 cases in each group.The experimental group received micro-punch excision com-bined with CO2 fractional laser treatment,while the control group received CO2 fractional laser monotherapy.Prior to treatment and three months after the first and second treatments,clinical ef-ficacy,ECCA scores,pain VAS scores,adverse reactions,anxiety scores,and patient satisfaction were compared between the two groups.Results Three months after the first treatment,the total effective rate in the experimental group was significantly higher than that in the control group(97.14％vs.82.86％,x2=8.57,P=0.003).Three months after the second treatment,the total effective rate in the experimental group remained higher than that in the control group(100％vs.82.86％,x2=13.79,P=0.006).Additionally,combination therapy significantly reduced acne scars(ECCA score)compared to the control group(18.91±9.05 vs.25.46±8.04,t=4.53,P＜0.05).Moreover,the pain VAS score was higher in the experimental group than in the control group(6.02±1.03 vs.4.96±1.92,t=4.07,P＜0.001).After the second treatment,patient satisfaction scores were also higher in the experimental group compared to the controls(8.89±1.35 vs.6.98±1.76,t=7.20,P＜0.001).The SAS score of the observation group was significantly higher than that of the control group after the first treatment(t=4.57,P＜0.001),but there was no significant difference after the second treatment(t=1.09,P=0.279).However,the incidence of adverse reactions was comparable between the two groups(P＞0.05).Conclusions Micro-punch excision combined with CO2 fractional laser therapy ex-hibits superior benefits compared to CO2 fractional laser monotherapy for the treatment of atrophic acne scars.This combination therapy can markedly improve acne scars,mitigate patient anxiety,and enhance patient satisfaction scores.关键词
痤疮/萎缩性瘢痕/环钻切除术/CO2点阵激光Key words
acne/atrophic scar/micro-punch resection/CO2 fractional laser引用本文复制引用
朱明明,翟慧娟,梁静,焦园园,康志楠,何坤铭,李晋雪,张钰沅..微型环钻切除术联合CO2点阵激光治疗萎缩性痤疮瘢痕的疗效与安全性评估[J].皮肤性病诊疗学杂志,2026,33(3):186-192,7.基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20230547) （LHGJ20230547）
