南京医科大学学报（自然科学版）2026，Vol.46Issue(4)：499-511,519,14.DOI:10.7655/NYDXBNSN251352
氨基酸代谢紊乱在卒中后认知障碍中的作用机制及研究进展
Mechanism and research progress of amino acid metabolic disorders in post-stroke cognitive impairment
摘要
Abstract
Post-stroke cognitive impairment(PSCI),as a common and highly disabling complication following stroke,not only severely impairs patients'quality of life but also significantly increases the risk of stroke recurrence and mortality.In the exploration of its pathogenesis,amino acid metabolic disorder has gradually been recognized as one of the key pathophysiological factors.Against this backdrop,this paper systematically reviews the research progress on major amino acid metabolic disorders in the core pathogenesis of PSCI in recent years,covering their underlying mechanisms,potential as biomarkers,and relevant interventional strategies,while highlighting their critical roles in neuroinflammation,oxidative stress,neurotransmitter imbalance,and other related aspects.These studies help deepen the understanding of the pathological mechanisms of PSCI,and also provide new insights and tools for early diagnosis,precise treatment,and prognostic evaluation of the disease,thus holding important clinical significance and potential application value.关键词
卒中后认知障碍/氨基酸代谢/代谢紊乱/神经炎症/氧化应激/生物标志物Key words
post-stroke cognitive impairment/amino acid metabolism/metabolic disorder/neuroinflammation/oxidative stress/biomarker分类
医药卫生引用本文复制引用
任琼迪,苏凯奇,张铭..氨基酸代谢紊乱在卒中后认知障碍中的作用机制及研究进展[J].南京医科大学学报（自然科学版）,2026,46(4):499-511,519,14.基金项目
国家自然科学基金青年基金(82305364) （82305364）
中国博士后科学基金面上项目(2025M773962) （2025M773962）
河南省中医学"双一流"创建科学研究专项(HSRP-DFCTCM-2023-3-11) （HSRP-DFCTCM-2023-3-11）
河南省中医药传承与创新人才工程(仲景工程)-拔尖人才(CZ0325-14) （仲景工程）
河南中医药大学研究生科研创新能力提升计划(2024KYCX020) （2024KYCX020）
