皮肤性病诊疗学杂志2026，Vol.33Issue(3)：219-222,4.DOI:10.3969/j.issn.1674-8468.2026.03.009
寻常型银屑病合并落叶型天疱疮1例
Psoriasis vulgaris complicated with pemphigus foliaceus:A case report
栾雪玉 1邵开心 1温禾 1于晓静1
作者信息
- 1. 山东大学齐鲁医院,山东 济南 250012
- 折叠
摘要
Abstract
A 50-year-old man presented with red papules,plaques,and desquamation for 15 years,as well as vesicles and desquamation for the past 25 days.He was diagnosed with psoriasis vulgaris a month ago and was treated with a subcutaneous injection of secukinumab at 300 mg weekly for 4 weeks.New vesicles and desquamation appeared on the trunk and limbs 25 days ago.A pemphigus antibody test showed Dsg1 at 222.76 U/mL,with Dsg3 and BP180 results negative.Histopathological examination showed focal parakeratosis with Munro microabscesses,as well as acantholytic cells in the superficial epidermis.Direct immunofluorescence revealed intercellular IgG(+++)and C3(++)between epidermal prickle cells.Diagnosis:Psoriasis vulgaris and pemphigus foliaceus.Treatment with prednisone and methotrexate for 11 weeks resulted in signifi-cant improvements in erythema,vesicles,and desquamation.关键词
寻常型银屑病/落叶型天疱疮Key words
psoriasis vulgaris/pemphigus foliaceus引用本文复制引用
栾雪玉,邵开心,温禾,于晓静..寻常型银屑病合并落叶型天疱疮1例[J].皮肤性病诊疗学杂志,2026,33(3):219-222,4.
