皮肤性病诊疗学杂志2026，Vol.33Issue(3)：223-228,6.DOI:10.3969/j.issn.1674-8468.2026.03.010
神经梅毒血脑屏障破坏机制与诊断标志物的研究进展
Research progress on blood-brain barrier disruption mechanisms and diagnostic biomarkers in neurosyphilis
摘要
Abstract
Treponema pallidum is capable of invading the central nervous system,thereby cau-sing neurosyphilis.The pathogenesis of neurosyphilis is closely related to the ability of T.pallidum to penetrate the blood-brain barrier.The clinical manifestations of neurosyphilis are diverse and of-ten lack specificity,which poses challenges for early diagnosis.Both domestic and international guidelines for the diagnosis of neurosyphilis indicate that diagnosis should be based on a compre-hensive assessment of epidemiological history,clinical manifestations,and laboratory test results.This article systematically reviews recent domestic and international literature on neurosyphilis,an-alyzes the cellular and molecular mechanisms underlying blood-brain barrier disruption by T.palli-dum,and summarizes the diagnostic value of differential cerebrospinal fluid metabolites,chemo-kines,proteins,and serum biomarkers,with the aim of providing references for the diagnosis of neurosyphilis.关键词
神经梅毒/梅毒螺旋体/血脑屏障/生物标志物/诊断Key words
neurosyphilis/Treponema pallidum/blood-brain barrier/biomarkers/di-agnosis引用本文复制引用
何佳臻,杨日东,黄茂芳,叶兴东,王焕丽..神经梅毒血脑屏障破坏机制与诊断标志物的研究进展[J].皮肤性病诊疗学杂志,2026,33(3):223-228,6.基金项目
广州市科技计划项目(2023A03J0469 （）
2024A03J0650) （）
