皮肤性病诊疗学杂志2026，Vol.33Issue(3)：236-242,7.DOI:10.3969/j.issn.1674-8468.2026.03.012
外阴阴道念珠菌病的阴道给药新剂型研究进展
Research progress on new drug formulations for vulvovaginal candidiasis via vaginal ad-ministration
摘要
Abstract
Vulvovaginal candidiasis(VVC)has a high incidence rate,and vaginal administra-tion is one of the main routes for its treatment.In recent years,there have been some advances in vaginal drug formulations.Among them,vaginal mucoadhesive gels can extend the retention time in the vagina;vaginal thermosensitive gels are easy to apply and dispense;vaginal films are small in volume,simple to prepare,and possess strong mucosal adhesion;vaginal sponges with dense voids have a large drug-loading capacity and can also achieve the purpose of targeted drug delivery through rational design;vaginal microspheres have high bioavailability,can improve drug solubili-ty,and enhance patient compliance;liquid crystal pre-formulations can reduce drug irritation and can also perform sustained and controlled drug release.These novel vaginal drug formulations can be used not only alone to exert therapeutic advantages but also in combination with existing tech-nologies,such as tablets and gels,to prepare composite formulations.This article will review the research progress of these new formulations that are being actively studied in the field of VVC treatment,aiming to provide a reference for the development of new vaginal formulations for VVC therapy.关键词
外阴阴道念珠菌病/阴道给药/新剂型/阴道制剂/药物Key words
vulvovaginal candidiasis/vaginal administration/new formulations/vaginal formulations/drugs引用本文复制引用
李宝杰,廖志刚,柴将红,游泽芳,刘朝晖..外阴阴道念珠菌病的阴道给药新剂型研究进展[J].皮肤性病诊疗学杂志,2026,33(3):236-242,7.基金项目
国家自然科学基金(81771530) （81771530）
