南京医科大学学报（自然科学版）2026，Vol.46Issue(4)：561-567,7.DOI:10.7655/NYDXBNSN251376
儿童及青少年组织细胞坏死性淋巴结炎临床特点及影响热程的危险因素分析
Clinical features and risk factors for fever duration in children and adolescents with histiocytic necrotizing lymphadenitis
摘要
Abstract
Objective:To analyze the clinical features,treatment,outcomes,and risk factors influencing fever duration in children and adolescents with histiocytic necrotizing lymphadenitis(HNL).Methods:A retrospective analysis was conducted on the clinical data of 35 pediatric HNL patients admitted to the First Affiliated Hospital of Nanjing Medical University.The clinical characteristics and risk factors were compared between the two groups:the short-duration fever group(≤2 weeks,n=17)and the long-duration fever group(>2 weeks,n=18).Results:Among the 35 patients,the mean age was(14.69±2.42)years,with a male-to-female ratio of 1.06∶1.All cases presented with lymphadenopathy,with cervical lymphadenopathy accounting for 85.7%,tenderness in 74.3%,and fever in 97.14%.Common laboratory abnormalities included elevated lactate dehydrogenase(65.7%),increased erythrocyte sedimentation rate(65.7%),leukopenia(62.86%),neutropenia(51.43%),elevated high-sensitivity C-reactive protein(54.29%),and elevated ferritin(45.71%);17.1%of patients tested positive for antinuclear antibody.The long-duration fever group had higher proportions of extra-cervical lymphadenopathy,leukopenia,neutropenia,antinuclear antibody positivity,and elevated inflammatory markers(P<0.05).Logistic regression indicated that elevated ferritin was an independent risk factor for prolonged fever duration.Antibiotics were ineffective in all 27 treated patients.In 22 patients,the median time to defervescence after glucocorticoid therapy following biopsy was 2 days,with the short-duration fever group showing faster fever resolution(P<0.05).During follow-up ranging from 6 months to 2 years,2 patients experienced recurrence,and none progressed to autoimmune diseases.Conclusion:HNL in children and adolescents primarily manifests with fever,painful cervical lymphadenopathy,leukopenia,and an elevated erythrocyte sedimentation rate.Elevated ferritin is an independent risk factor for prolonged fever duration.Diagnosis relies on lymph node biopsy,antibacterial therapy is generally ineffective,and glucocorticoid treatment demonstrates favorable efficacy.关键词
组织细胞坏死性淋巴结炎/儿童/青少年/临床特点/治疗Key words
histiocytic necrotizing lymphadenitis/children/adolescents/clinical characteristics/treatment分类
医药卫生引用本文复制引用
陆彬彬,王文婷,陆超,李俊霞,李赟颉,濮亚宁,韩婷婷,邹黎..儿童及青少年组织细胞坏死性淋巴结炎临床特点及影响热程的危险因素分析[J].南京医科大学学报（自然科学版）,2026,46(4):561-567,7.基金项目
江苏省人民医院妇幼高质量发展科研专项-青年项目(GZL2503) （GZL2503）
