南京医科大学学报（自然科学版）2026，Vol.46Issue(4)：598-606,9.DOI:10.7655/NYDXBNSN251438
PFKM通过经典与非经典途径调控巨噬细胞功能的研究进展
Research progress on the regulation of macrophage function by PFKM through classical and non-classical pathways
摘要
Abstract
Phosphofructokinase,muscle type(PFKM)is a key rate-limiting enzyme in the glycolytic pathway,and its expression and activity are regulated by multiple signaling pathways,including hypoxia-inducible factor-1 alpha(HIF-1α),myelocytomatosis oncogene(Myc),phosphoinositide 3-kinase/protein kinase B(PI3K/AKT),and adenosine 5′-monophosphate(AMP)-activated protein kinase(AMPK).Recent studies have demonstrated that PFKM reprograms macrophage functions through both the canonical glycolytic pathway and"non-canonical"functions.Physicochemical factors in the microenvironment,including mechanical forces,glucose,and citrate,can shift the equilibrium between the tetrameric and dimeric conformations of PFKM,thereby facilitating the switch between its classical and non-classical functions.While current research has largely focused on the classical glycolytic role of PFKM,its non-canonical functions and the underlying molecular mechanisms remain to be fully elucidated.This review summarizes the classical and non-canonical roles of PFKM in macrophages,its upstream regulatory signals,and its implications in infectious diseases and cancer,aiming to provide a theoretical foundation and insights for PFKM-targeted immunometabolic therapeutic strategies.关键词
磷酸果糖激酶肌型/糖酵解/巨噬细胞/感染/肿瘤Key words
phosphofructokinase muscle type/glycolysis/macrophages/infection/tumor分类
医药卫生引用本文复制引用
姚晨,杨晶,潘宇晨..PFKM通过经典与非经典途径调控巨噬细胞功能的研究进展[J].南京医科大学学报（自然科学版）,2026,46(4):598-606,9.基金项目
国家自然科学基金(82502134) （82502134）
