兰州大学学报（医学版）2026，Vol.52Issue(2)：1-7,7.DOI:10.13885/j.issn.2097-681X.M20251616
巨噬细胞在缺血再灌注损伤和再生中的机制研究进展
Advances in research on the mechanisms of macrophages in ischemia-reperfusion injury and regeneration
摘要
Abstract
Ischemia reperfusion injury is an extremely complex pathophysiological process that occurs widely in organ transplantation,myocardial infarction,stroke and other procedures.Macrophages,as central players in the immune system,has a crucial role in injury regeneration following ischemia-reperfusion.Classically ac-tivated M1 macrophages mediate the early inflammatory storm and tissue damage,while alternatively activat-ed M2 macrophages dominate the later stages of inflammation resolution,tissue repair and regeneration.The dynamic balance between macrophage phenotypes is critical for the outcome of ischemia-reperfusion injury.This review summarized the role of macrophages in ischemia-reperfusion injury and regeneration,covering their dual roles in ischemia-reperfusion injury and in the complex networks regulating their dynamic polariza-tion.Furthermore,the review highlighted various potential therapeutic strategies targeting macrophages in ischemia-reperfusion injury,aiming to provide insights for research related to ischemia-reperfusion injury and regeneration.关键词
巨噬细胞/缺血再灌注损伤/再生/免疫调控/代谢重编程/细胞疗法Key words
macrophages/ischemia reperfusion injury/regeneration/immunoregulation/metabolic reprogram-ming/cell therapy分类
医药卫生引用本文复制引用
陈元明,武子硕,徐骁,鲁迪..巨噬细胞在缺血再灌注损伤和再生中的机制研究进展[J].兰州大学学报（医学版）,2026,52(2):1-7,7.基金项目
国家科技重大专项(2024ZD0529000) （2024ZD0529000）
