兰州大学学报（医学版）2026，Vol.52Issue(2)：16-22,7.DOI:10.13885/j.issn.2097-681X.M20250543
CT多参数联合临床因素预测胰腺导管腺癌术后新发非酒精性脂肪性肝病
Multiple CT parameters combined with clinical factors for predicting newly-onset non-alcoholic fatty liver disease after pancreatic ductal adenocarcinoma surgery
摘要
Abstract
Objective Aims to evaluate the predictive value of multi-parametric computed tomography(CT)parameters combined with clinical factors for non-alcoholic fatty liver disease(NAFLD)folowing pancreatic ductal adenocarcinoma surgery.Methods 145 pancreatic ductal adenocarcinoma patients were retrospective-ly enrolled and divided into a NAFLD group and a non-NAFLD group based on whether the unenhanced he-patic CT attenuation values were less than 40 HU six months after surgery.CT parameters such as extracellu-lar volume fraction(ECV),arterial enhancement fraction in two weeks before surgery,remnant pancreatic vol-ume(RPV)in one month after surgery and clinical characteristics were compared between the two groups,and the independent factors for predicting NAFLD were identified using a binary Logistic regression analysis to establish a model.The predictive performance of NAFLD were evaluated using receiver operating charac-teristics.Results Six months after pancreatic ductal adenocarcinoma surgery,29(20.00%)patients were diag-nosed with NAFLD.Sex,ECV and RPV were identified as independent predictors of NAFLD(all P<0.05).Compared with the non-NAFLD group,patients in the NAFLD group had a higher proportion of females,higher ECV and lower RPV(all P<0.001).The area under the curve(AUC)of ECV,RPV,and the combined clinical-radiological model for predicting NAFLD were 0.863(95%CI:[0.778,0.948]),0.842(95%CI:[0.767,0.917]),0.937(95%CI:[0.877,0.997]),respectively.The combined model had a higher AUC than ECV(P<0.001),but not significantly different from that of RPV(P=0.061).Conclusion The clinical-radiological model incorporating sex and CT-derived parameters(ECV and RPV)was effective for predicting newly-onset NAFLD after pancreatic ductal adenocarcinoma surgery.关键词
非酒精性脂肪性肝病/计算机体层成像/细胞外容积分数/胰腺导管腺癌/胰腺残余体积Key words
non-alcoholic fatty liver disease/computed tomography/extracellular volume fraction/pancreatic ductal adenocarcinoma/residual pancreatic volume分类
医药卫生引用本文复制引用
蒋鑫垚,赵楠,赵盈,雷军强..CT多参数联合临床因素预测胰腺导管腺癌术后新发非酒精性脂肪性肝病[J].兰州大学学报（医学版）,2026,52(2):16-22,7.基金项目
甘肃省精准影像协同创新甘肃省合作基地 （）
