兰州大学学报（医学版）2026，Vol.52Issue(2)：60-71,12.DOI:10.13885/j.issn.2097-681X.M20251045
抗逆转录病毒疗法治疗艾滋病疗效与安全性的网状Meta分析
The comparative efficacy of antiretroviral therapies for acquired immunodeficiency syndrome:a network meta-analysis
摘要
Abstract
Objective To compare the efficacy and safety of different antiretroviral therapy regimens.Methods Randomized controlled trialsrelated antiretroviral therapies for acquired immunodeficiency syn-drome were systematically retrieved from domestic and international databases.The Cochrane Risk of Bias Tool was used to assess the quality of the randomized controlled trials.Data analysis was per-formed using Stata 17.0 software,with effect sizes expressed as odds ratios and 95%confidence intervals.Interventions were ranked using the surface under the cumulative ranking curve values.Results A total of 36 randomized controlled trials were included,of which 19 studies were assessed as having moder-ate-to-low risk of bias.Network meta-analysis results showed that regimens based on newer integrase strand transfer inhibitors dem-onstrated significant advantages in both short-term(48-week)and long-term(96-week)antiviral efficacy.At 48 weeks,the tenofovir alafenamide+emtricitabine+dolutegravir and tenofovir alafen-amide+emtricitabine+bictegravir regimens achieved significantly higher viral suppression rates compared to several traditional regi-mens based on non-nucleoside reverse transcriptase inhibitors or earlier protease inhib-itors.At 96 weeks,DTG-based regimens(including tenofovir disoproxil fumarate+emtricitabine+dolutegravir and abacavir+lami-vudine+dolutegravir)showed significantly higher viral suppression rates than traditional regimens and were superior to the 48-week tenofovir alafenamide+emtricitabine+dolutegravir regimen.No significant differences in the incidence of adverse events were observed among the different regimens.Conclusion The the tenofovir alafenamide+emtricitabine+dolutegravir and tenofovir disoproxil fumarate+emtricitabine/lamivudine+rilpiv-irine regimens demonstrated relatively better efficacy and safety,potentially offering reliable long-term antivi-ral treatment options for acquired immune deficiency syndrome patients.关键词
艾滋病/抗逆转录病毒疗法/网状Meta分析/疗效/安全性/治疗方案/随机对照研究Key words
acquired immunodeficiency syndrome/antiretroviral therapy/network Meta-analysis/efficacy/safeness/therapeutic regimen/randomized controlled trial分类
医药卫生引用本文复制引用
李盛,宁金铃,韩敏,马艳,王金玉,施文娟,万红,葛龙..抗逆转录病毒疗法治疗艾滋病疗效与安全性的网状Meta分析[J].兰州大学学报（医学版）,2026,52(2):60-71,12.基金项目
甘肃省科技计划项目(23JRRA1457) （23JRRA1457）
兰州市科技计划项目(2024-9-204,2025-2-28) （2024-9-204,2025-2-28）
兰州市城关区科技计划项目(2024-11-14) （2024-11-14）
