兰州大学学报（医学版）2026，Vol.52Issue(2)：105-110,6.DOI:10.13885/j.issn.2097-681X.M20240583
维生素D干预铁死亡在糖尿病及其并发症中的研究进展
Progress in research on vitamin D targeted regulation of ferroptosis in diabetes mellitus and its complications
摘要
Abstract
Ferroptosis is a new form of regulatory cell death,mainly characterized by the accumulation of lip-id reactive oxygen species and the deposition of large amounts of iron,which is different from cell necrosis,apoptosis and autophagy.Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia,which is characterized by insufficient insulin secretion due to insulin resistance and dysfunction of islet beta cells.Pancreatic beta cells are more sensitive to oxidative stress,and thus are susceptible to ferroptosis.Vita-min D has anti-inflammatory and immunomodulatory effects.In recent years,the research on vitamin D regu-lating ferroptosis pathway to improve diabetes has become a hot topic.This article focused on the mechanism of vitamin D intervention in ferroptosis in diabetes and its complications,in order to provide a reference for it.关键词
维生素D/铁死亡/糖尿病/糖尿病并发症/谷胱甘肽/酰基辅酶A合成酶长链家族成员4/核因子-红细胞2相关因子2/血红素加氧酶1Key words
vitamin D/ferroptosis/diabetes mellitus/diabetic complication/reduced glutathione/long-chain acyl-coenzyme A synthase 4/nuclear factor erythroid 2-related factor 2/heme oxygenase 1分类
医药卫生引用本文复制引用
白娟霞,权金星,郭文艳,毛华博,李晓芬,刘菊香..维生素D干预铁死亡在糖尿病及其并发症中的研究进展[J].兰州大学学报（医学版）,2026,52(2):105-110,6.基金项目
国家自然科学基金资助项目(81960160) （81960160）
甘肃省自然科学基金资助项目(24JRRA1060) （24JRRA1060）
