数据采集与处理2026，Vol.41Issue(2)：416-438,23.DOI:10.16337/j.1004-9037.2026.02.008
医学影像-病理-基因融合的智能分析和诊疗应用
Medical Imaging-Pathology-Genomic Fusion and Its Applications in Clinical Diagnosis and Treatment
摘要
Abstract
Medical imaging,pathology,and genomics respectively provide information on tumor spatial-morphological phenotypes,histopathological architecture,and molecular mechanisms.Single-modal approaches are constrained by scale discrepancies,sampling biases,and cross-center domain shifts,limiting their support for clinical decision-making.For precision oncology,imaging-pathology-genomics integration aims at semantical alignment and consistency validation among macroscopic imaging,microscopic histological,and mechanistic molecular evidence.This review systematically examines the field via fusion methodologies and clinical applications.We discuss the clinical advantages of multimodal integration,summarize key fusion paradigms,and emphasize its clinical necessity.In applications,focusing on completing the clinical evidence chain,we summarize its advantages in differential diagnosis,molecular subtyping,surgical planning,treatment response stratification,and systematic decision output,highlighting how integration turns predictive results into verifiable,actionable clinical decisions via cross-modal validation.Finally,we discuss emerging trends:spatial omics with multi-region sampling,longitudinal tumor evolution modeling,multimodal foundation models,and multi-center collaborative validation.We propose clinical translation recommendations and a utility evaluation system,offering a roadmap for next-generation intelligent multimodal systems in precision oncology.关键词
多模态融合/影像病理组学/影像基因组学/精准肿瘤学Key words
multimodal fusion/radiopathomics/radiogenomics/precision oncology分类
医药卫生引用本文复制引用
段静娴,赵源深,康梁钰淇,梁栋,郑海荣,李志成..医学影像-病理-基因融合的智能分析和诊疗应用[J].数据采集与处理,2026,41(2):416-438,23.基金项目
深圳市医学研究专项资金(A2303008) （A2303008）
国家自然科学基金(T2525037,62201557,62571523) （T2525037,62201557,62571523）
广东省"特支计划"(2024TX08A213) （2024TX08A213）
深圳市科技计划项目(JCYJ20250604183020027,JCYJ20241202125014018) （JCYJ20250604183020027,JCYJ20241202125014018）
中国科学院战略性先导科技专项(B类)(XDB0930302). Shenzhen Medical Research Fund(No.A2303008) （B类）
National Natural Science Foundation of China(Nos.T2525037,62201557,62571523) （Nos.T2525037,62201557,62571523）
Guangdong Special Support Plan(No.2024TX08A213) （No.2024TX08A213）
Shenzhen Science and Technology Pro-gram(Nos.JCYJ20250604183020027,JCYJ20241202125014018) （Nos.JCYJ20250604183020027,JCYJ20241202125014018）
Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0930302). （No.XDB0930302）
