生物医学工程研究2026，Vol.45Issue(1)：15-21,7.DOI:10.19529/j.cnki.1672-6278.2026.01.03
基于神经核团谐振的经皮电刺激睡眠调控方法与效果评估
Sleep modulation method and effects evaluation of transcutaneous electrical nerve stimulation based on neural nuclei resonance
摘要
Abstract
To examine the sleep-modulatory effects of transcutaneous electrical nerve stimulation(TENS)based on neural nuclei resonance,30 healthy participants were assigned to either a sham stimulation group or a TENS(123~127 Hz)group,each group was intervened 30 min.Sleep electroencephalogram(EEG)was recorded for 60 min and evaluated using both objective and subjective measures.The results showed that among participants with poor sleep quality,the TENS group exhibited bidirectional emotional im-provements,with increased positive emotions(P＝0.048)and decreased negative emotions(P＝0.002).TENS decreased the gravity frequency of EEG(P＝ 0.009),and reduced neuronal discharge frequency with stable dominance of δ and θ activity during sleep.Mo-reover,sleep efficiency increased,the proportion of N3 sleep was enhanced,the stability of N2 and N3 stages improved,and abnormal arousals were reduced.The research demonstrate that TENS with specific frequency waveforms effectively promotes low-frequency EEG activity,optimizes sleep architecture and improves emotional state,offering a novel non-pharmacological intervention for insomnia.关键词
脑电信号/经皮神经电刺激/睡眠调控/激活比/重心频率/睡眠分期Key words
Electroencephalogram signal/Transcutaneous electrical nerve stimulation/Sleep modulation/Activation ratio/Gravity frequency/Sleep staging分类
医药卫生引用本文复制引用
单智超,张煜恒,娄亚君,王雪靖,徐凡尧,钱志余..基于神经核团谐振的经皮电刺激睡眠调控方法与效果评估[J].生物医学工程研究,2026,45(1):15-21,7.基金项目
国家自然科学基金项目(82151311) （82151311）
江苏省自然科学基金项目(BK20251377) （BK20251377）
中央高校基本科研业务费项目(NP2024102). （NP2024102）
