日用化学品科学2026，Vol.49Issue(4)：42-46,5.DOI:10.3969/j.issn.1006-7264.2026.04.007
视黄醇棕榈酸酯醇质体的制备及其表征研究
Preparation and characterization of retinyl palmitate phytosomes
张勇军 1刘瑞学 1谢思诗 1谈小芳 1李适炜 2陈家享2
作者信息
- 1. 广东芭薇生物科技股份有限公司,广东 广州 510450
- 2. 广东悠质检测技术有限公司,广东 广州 510450
- 折叠
摘要
Abstract
Retinyl palmitate phytosomes(RP-E)were prepared using ultra-high-pressure microfluidization.Characterization showed that the phytosomes were spherical or ellipsoidal,exhibiting a phospholipid bilayer structure.The average particle size was 39.18 nm(PDI=0.143),and the zeta potential was-37.95 mV,indicating excellent dispersion stability.HPLC analysis confirmed the RP content of 4.99%,and ultracentrifugation revealed an encapsulation efficiency of 99.8%.Stability studies demonstrated that particle sizes remained below 50 nm under various storage conditions(room temperature,light exposure,-15 ℃,45℃,alternating temperature,and 5℃),and the active ingredient content exceeded 4.5%under all conditions except 45 ℃ and alternating temperature,corresponding to degradation rates below 10%.This process not only effectively protects retinol derivatives but also shows strong potential for industrial-scale production,providing an innovative strategy for nano-encapsulation of retinoid raw materials.关键词
视黄醇棕榈酸酯/醇质体/微射流/包封率/稳定性Key words
retinyl palmitate/phytosomes/microfluidization/encapsulation efficiency/stability分类
化学化工引用本文复制引用
张勇军,刘瑞学,谢思诗,谈小芳,李适炜,陈家享..视黄醇棕榈酸酯醇质体的制备及其表征研究[J].日用化学品科学,2026,49(4):42-46,5.
