青岛大学学报（医学版）2026，Vol.62Issue(1)：76-79,4.DOI:10.11712/jms.2096-5532.2026.62.041
基于非门控胸部CT的冠状动脉钙化与冠状动脉狭窄程度相关性
Association of coronary artery calcification on non-gated chest CT with the severity of coronary artery stenosis
摘要
Abstract
Objective To investigate the association of coronary artery calcification(CAC)assessed by non-gated chest CT with coronary heart disease(CHD)and the severity of coronary artery stenosis.Methods A retrospective analysis was per-formed for 2 105 patients suspected of CHD who underwent both invasive coronary angiography and chest CT examination in Huai'an No.1 People's Hospital Affiliated to Nanjing Medical University from January to December 2022.According to the Agat-ston score,the patients were divided into non-calcification group,mild calcification group,moderate calcification group,and severe calcification group.The 528 patients with coronary artery stenosis ≤50％were included in the control group,while the 1 577 pa-tients with coronary artery stenosis＞50％were included in the CHD group.Baseline data and CAC distribution were compared be-tween the two groups.The multivariate logistic regression analysis was used to investigate the association between CAC and CHD,and the chi-square test was used to analyze the correlation between CAC and the severity of stenosis.Results Compared with the control group,the CHD group had significantly higher age,proportion of male patients,smoking rate,prevalence rate of dia-betes,and level of triglyceride(x2=15.935-34.498,Z=—4.925,—2.863,P＜0.05).The degree of CAC was significantly associ-ated with CHD(x2=297.480,P＜0.001).The severity of coronary artery stenosis increased significantly with the increase in the degree of calcification(x2=437.641,P＜0.001).CAC was an independent risk factor for CHD,and the risk of developing CHD in the mild,moderate,and severe calcification groups was 3.39,11.46,and 27.39 times,respectively,that in the non-calcification group(P＜0.001).Conclusion CAC assessed by non-gated chest CT is significantly associated with CHD and the severity of coronary artery stenosis,which provides a reference for the diagnosis of CHD and the assessment of disease severity.关键词
冠心病/冠状动脉狭窄/体层摄影术,螺旋计算机/冠状动脉钙化积分Key words
coronary disease/coronary stenosis/tomography,spiral computed/Agatston score分类
医药卫生引用本文复制引用
杜秋瑶,刘梦婕,倪天祎,耿金,陈晓晓,王丙剑..基于非门控胸部CT的冠状动脉钙化与冠状动脉狭窄程度相关性[J].青岛大学学报（医学版）,2026,62(1):76-79,4.基金项目
江苏省卫生健康委员会科研面上项目(H20230-86) （H20230-86）
淮安市心脑血管重点实验室(HAP202202) （HAP202202）
苏州工业园区东方华夏心血管健康研究院-天然调脂药物循证科研基金项目(2023-CCA-NLD-055) （2023-CCA-NLD-055）
