四川中医2026，Vol.44Issue(3)：49-57,9.DOI:10.26946/j.cnki.1000-3649.sczy.2506030005
保元汤加减联合督灸对阳气亏虚血瘀证非HFrEF患者的影响
Effect of combined use of modified Baoyuan Decoction and Du-Moxibustion on patients with heart failure with non-reduced ejection fraction due to Yang Qi deficiency and blood stasis
摘要
Abstract
Objectives To observe the effect of modified Baoyuan Decoction combined with Du-moxibustion on patients with heart failure(HF)with non-reduced ejection fraction(HFrEF)due to Yang Qi deficiency and blood stasis,and to preliminarily evaluate its clinical efficacy and safety.Methods The study subjects were 76 non-HFrEF patients who visited the Beijing University of Chinese Medicine Shenzhen Hospital(Longgang)from January 2023 to October 2024.The patients were randomly divided into a conventional treatment group(RT group)and a combined treatment group of modified Baoyuan Decoction and Du-moxibustion(BYDDM group),with 39 patients in the RT group and 37 patients in the BYDDM group.The RT group was treated with standard Western medicine treatment,while the BYDDM group was treated with modified Baoyuan Decoction combined with Du-moxibustion on the basis of standard Western medicine treatment.The observation period was 4 weeks.Changes in blood viscosity-related indicators(HCT,RDW,RDW-CV,PLT,PCT),FS-14 scale score,KCCQ-12 score,and cardiac function indicators(NT-proBNP,LVEF,FS,LA,and LV)were compared between the two groups before and after treatment.The clinical efficacy,liver and kidney function(ALT,AST,Scr,BUN),coagulation function indicators(PT,APTT,and D-D),and incidence of adverse events were also compared between the two groups.Results After the combined application of modified Baoyuan decoction and Du-moxibustion treatment,the FS-14 score and the NT-proBNP level were significantly reduced(P<0.01).And the KCCQ-12 score significantly improved(P<0.01).The clinical efficacy and TCM syndrome relief efficacy were also better(P<0.01 and P<0.001,respectively)than that of the RT group.The LVEF and FS values in both groups were significantly increased after treatment(P<0.05),but no significant difference was observed.After treatment,the LV value decreased(P<0.05),but still no significant statistical difference was found in LA and LV values between the two groups after treatment(P>0.05).The level of ALT,AST,Scr,BUN,PT,APTT,and D-D were still in the normal ranges after intervention.Conclusions Modified Baoyuan Decoction combined with Du-moxibustion has significant therapeutic effects on non-HFrEF patients with Yang Qi deficiency and blood stasis syndrome.It can effectively improve blood viscosity,reduce fatigue,improve quality of life,enhance cardiac function,and improve overall symptoms with no significant impact on the liver,kidney and coagulating system,indicating a favorable safety profile that worths wide clinical application.关键词
保元汤加减/督灸/阳气亏虚血瘀证/非HFrEFKey words
Modified Baoyuan decoction/Du-moxibustion/Yang Qi deficiency and blood stasis syndrome/Heart failure with non-reduced ejection fraction分类
医药卫生引用本文复制引用
吴佳芸,蔡小静,徐则,彭衍,杨金果..保元汤加减联合督灸对阳气亏虚血瘀证非HFrEF患者的影响[J].四川中医,2026,44(3):49-57,9.基金项目
龙岗区科技创新局课题(LGWJ2022-80). （LGWJ2022-80）
