四川中医2026，Vol.44Issue(3)：95-102,8.DOI:10.26946/j.cnki.1000-3649.sczy.2509260005
祛风清热、活血养血法治疗过敏性结膜炎的机理研究
Study on the mechanism of expelling wind and clearing away heat,promoting blood circulation and nourishing blood in the treatment of allergic conjunctivitis
摘要
Abstract
Objective To explore the mechanism of expelling wind and clearing away heat,promoting blood circulation and nourishing blood in the treatment of allergic conjunctivitis.Methods Based on the traditional Chinese medicine(TCM)inheritance assistant system and network pharmacology,the new prescription of TCM for allergic conjunctivitis was explored,to analyze and predict the targets and mechanism of new compound(Saposhnikoviae Radix,Schizonepetae Herba,Cicadae Periostracum,Chuanxiong Rhizoma,Scutellariae Radix,Angelicae Sinensis Radix,Rehmanniae Radix,Paeoniae Radix Rubra,Chrysanthemi Flos,Glycyrrhizae Radix et Rhizoma)in the intervention of allergic conjunctivitis.Result With CNKI,VIP and other databases as the source of search,according to certain requirements for retrieval and elimination,a total of 131 prescriptions were included in the TCM inheritance auxiliary system platform.The most frequently used drugs were Saposhnikoviae Radix,Glycyrrhizae Radix et Rhizoma,Schizonepetae Herba,Cicadae Periostracum,Chuanxiong Rhizoma,etc.The analysis of drug properties mainly focused on cold and warm drugs,and bitter,sweet and pungent drugs appeared frequently.The top 10 drugs by frequency association in network pharmacology analysis(New Compound-Qufeng Zhiyang Yihao decoction)have 125 active ingredients,251 target genes,and 1,154 disease target genes for allergic conjunctivitis.There were 53 intersection target genes for the intervention of new compound in allergic conjunctivitis.The key target genes of Qufeng Zhiyang Yihao decoction in treating allergic conjunctivitis mainly include MAPK3,MMP9,MMP2,IL-1B,IKBKB and so on.Qufeng Zhiyang Yihao prescription mainly affects the response of allergic conjunctivitis to cellular oxidative stress,transcription factor binding and positively regulates cell migration through MAPK signaling pathway,AGE-RAGE signaling pathway and calcium signaling pathway.Conclusion TCM treats the allergic conjunctivitis to adopt dispelling wind and clearing away heat,promoting blood circulation and nourishing blood method.Qufeng Zhiyang Yihao decoction may play a role in the treatment of allergic conjunctivitis by regulating the expression of MAPK3,MMP9,MMP2,IL-1B,IKBKB and other genes,and regulating MAPK,AGE-RAGE and calcium signaling pathways.关键词
祛风清热/活血养血/过敏性结膜炎/MAPK/免疫调节Key words
Expelling wind and clearing away heat/Promoting blood circulation and nourishing blood/Allergic conjunctivitis/MAPK/Immunoregulation分类
医药卫生引用本文复制引用
赵凡,樊永华,史昱,喻京生,叶勇..祛风清热、活血养血法治疗过敏性结膜炎的机理研究[J].四川中医,2026,44(3):95-102,8.基金项目
湖南省长沙市自然科学基金项目(kq2202449) （kq2202449）
陕西省咸阳市科技计划项目(QCYJJQ-2024-277) （QCYJJQ-2024-277）
十四五第一批中医药学科带头人(ptczxm-rsk-2022028). （ptczxm-rsk-2022028）
