生殖医学杂志2026，Vol.35Issue(3)：411-417,7.DOI:10.3969/j.issn.1004-3845.2026.03.019
精索静脉曲张损伤睾丸生精功能的机制及中药干预研究进展
Research progress in the mechanism of testicular spermatogenic function damage caused by varicocele and intervention with traditional Chinese medicine
摘要
Abstract
Varicocele refers to a vascular disease in which the plexus of veins within the spermatic cord is abnormally elongated,dilated,and tortuous.It is a common cause of male infertility.Numerous studies have shown that varicocele can damage the spermatogenic function of the testes through various mechanisms such as inducing oxidative stress damage,promoting apoptosis of spermatogonia,triggering chronic inflammatory reactions,and interfering with steroid hormone synthesis,thereby reducing male fertility.There is currently no specific drug for varicocele in clinical practice.And traditional Chinese medicine,with its multi-component,multi-target,and multi pathway characteristics,has shown unique advantages in improving testicular spermatogenic function damage caused by varicocele.Although there are relevant literature on the mechanism of testicular spermatogenic function damage caused by varicocele both domestically and internationally,there is currently a lack of systematic review and summary of traditional Chinese medicine in this field.Therefore,this article summarizes the relevant mechanisms of testicular spermatogenic function damage caused by varicocele and the research progress related with traditional Chinese medicine intervention,in order to provide a reference for the clinical application and in-depth research of traditional Chinese medicine in this field.关键词
精索静脉曲张/男性不育症/中医药/作用机制/研究进展Key words
Varicocele/Male infertility/Traditional Chinese medicine/Mechanism of action/Research progress分类
医药卫生引用本文复制引用
黄念文,白遵光,古炽明,杨世坚,黄钦展,毕焕洲,袁少英..精索静脉曲张损伤睾丸生精功能的机制及中药干预研究进展[J].生殖医学杂志,2026,35(3):411-417,7.基金项目
国家自然科学基金(82274532) （82274532）
广东省中医药局科研项目(20231308) （20231308）
重大疑难疾病中西医临床协作项目(ZDYN-2024-A-046) （ZDYN-2024-A-046）
