护理研究2026，Vol.40Issue(8)：1249-1256,8.DOI:10.12102/j.issn.1009-6493.2026.08.002
睡眠特征与便秘发生风险的遗传关联分析及机制探索
Genetic association analysis and mechanism exploration between sleep characteristics and the risk of constipation
摘要
Abstract
Objective:To explore the genetic causal association between six sleep characteristics and constipation using Mendelian randomization analysis.Methods:This study selected the genome-wide association study data of six sleep characteristics from the OpenGWAS database of the Medical Research Council Integrative Epidemiology Unit at University of Bristol and the genome-wide association study data of constipation from the catalog database of Genome Wide Association Study.The inverse variance weighted method(IVW)was adopted as the main analysis method to evaluate the causal relationship between the six sleep characteristics and constipation.MR-Egger and weighted median method(WM)were used as supplementary evidence for the IVW results.At the same time,heterogeneity and horizontal pleiotropy tests were conducted to ensure the stability of the results.The instrumental variables of the positive results were annotated,and enrichment analysis of related genes was performed to predict their potential mechanisms.Results:The IVW method results showed that insomnia increased the risk of constipation(P=0.002),and sleep duration also affected constipation(P=0.026).Sensitivity analysis indicated that the results were stable.Gene enrichment analysis revealed that insomnia may affect the occurrence of constipation through the immune system pathway,while sleep duration may exert its effect through mechanisms such as regulating the intestinal-brain neural function and catecholamine secretion.Conclusions:Insomnia is a risk factor for constipation.Ensuring adequate sleep has guiding significance for the prevention and treatment of constipation.关键词
便秘/睡眠特征/孟德尔随机化/失眠/机制/护理Key words
constipation/sleep characteristics/Mendelian randomization/insomnia/mechanism/nursing引用本文复制引用
吴新悦,莫灵玲,杨孔铭,陈闯..睡眠特征与便秘发生风险的遗传关联分析及机制探索[J].护理研究,2026,40(8):1249-1256,8.基金项目
广西中医药重点学科建设项目,编号:GZXK-Z-20-18 （）
