沈阳医学院学报2026，Vol.28Issue(2)：113-118,145,7.DOI:10.16753/j.cnki.1008-2344.2026.02.001
基于外泌体的肺部靶向递送:间充质干细胞外泌体雾化吸入治疗在呼吸系统疾病的研究与转化挑战
Exosome-based targeted pulmonary delivery:nebulization inhalation of mesenchymal stem cell-derived exosome in respiratory diseases research and translational challenges
摘要
Abstract
Mesenchymal stem cell-derived exosomes(MSC-Exos)have attracted attention due to their rich bioactive substances and low immunogenic properties.Nebulization inhalation,as a non-invasive and targeted pulmonary delivery method,has opened up new avenues for the application of MSC-Exos in respiratory diseases.This article systematically reviews the characteristics of MSC-Exos,the mechanisms of nebulization inhalation,as well as the efficacy in respiratory diseases,the challenges faced in clinical translation,and the future development directions,aiming to provide a theoretical basis for the preclinical research and clinical translation of this emerging therapeutic strategy.关键词
间充质干细胞/外泌体/雾化吸入/肺部疾病/药物递送/再生医学Key words
mesenchymal stem cells/exosomes/nebulization inhalation/pulmonary diseases/drug delivery/regenerative medicine分类
医药卫生引用本文复制引用
夏书月..基于外泌体的肺部靶向递送:间充质干细胞外泌体雾化吸入治疗在呼吸系统疾病的研究与转化挑战[J].沈阳医学院学报,2026,28(2):113-118,145,7.基金项目
辽宁省自然科学基金联合基金(No.2023-MSLH-301) （No.2023-MSLH-301）
辽宁省教育厅面上项目(No.LJ212410164012) （No.LJ212410164012）
