眼科学报2026，Vol.41Issue(3)：184-195,12.DOI:10.12419/25060901
无防腐剂0.4%盐酸奥布卡因滴眼液在激光角膜屈光手术疼痛管理方案的应用研究
Application research of preservative-free 0.4%oxybuprocaine hydrochloride eye drops in pain management protocol in laser corneal refractive surgery
魏妮娜 1刘伟民 1陈霞 1黄舒甜 1陈冬燕 1朱良勇1
作者信息
- 1. 南宁爱尔眼科医院屈光科,南宁 530003
- 折叠
摘要
Abstract
Objective:To evaluate the efficacy of preservative-free 0.4%oxybuprocaine hydrochloride eye drops in pain management during small incision lenticule extraction(SMILE)and femtosecond laser-assisted laser in situ keratomileusis(FS-LASIK),and to investigate its anesthetic effect and safety profile.Methods:A total of 1 560 patients(3 120 eyes)who underwent corneal refractive surgery in the Refractive Surgery Department from December 2023 to March 2024 were selected,including 780 cases(1 560 eyes)of SMILE and 780 cases(1 560 eyes)of FS-LASIK.All patients were given preservative-free 0.4%oxybuprocaine hydrochloride eye drops 1 minute before surgery.Pain was assessed using the Numerical Rating Scale(NRS)during surgery and at 5 minutes postoperatively.Intraoperative corneal complications and patient cooperation were also recorded.Results:Preservative-free 0.4%oxybuprocaine hydrochloride eye drops effectively alleviated intraoperative and postoperative pain.The median NRS scores during and after surgery were 0(0,0)in both the SMILE and FS-LASIK groups.The incidence of intraoperative corneal complications was low,with corneal epithelial injury rates of 0.2%in the SMILE group and 0.3%in the FS-LASIK group.Patient cooperation during surgery was excellent,with rates of 98%in the SMILE group and 96%in the FS-LASIK group.No adverse reactions related to the study drug were observed.Conclusions:Preservative-free 0.4%oxybuprocaine hydrochloride eye drops demonstrate a good anesthetic effect and high safety profile in laser corneal refractive surgery,providing patients with a better treatment experience and representing an effective option for perioperative management.关键词
无防腐剂0.4%奥布卡因滴眼液/激光角膜屈光手术/疼痛管理Key words
preservative-free 0.4%oxybuprocaine hydrochloride eye drops/laser corneal refractive surgery/pain management分类
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魏妮娜,刘伟民,陈霞,黄舒甜,陈冬燕,朱良勇..无防腐剂0.4%盐酸奥布卡因滴眼液在激光角膜屈光手术疼痛管理方案的应用研究[J].眼科学报,2026,41(3):184-195,12.
