眼科学报2026，Vol.41Issue(3)：240-252,13.DOI:10.12419/25052204
视网膜母细胞瘤钙化容积CT影像特征和临床应用价值
CT imaging features and clinical application significance of calcification volume in retinoblastoma
摘要
Abstract
Objective:To evaluate the calcification level of retinoblastoma(RB)lesions using image post-processing system software,such as that for computed tomography(CT)noncontrast scanning and three-dimensional reconstruction.Additionally,this study aimed to explore the relationship between retinoblastoma(RB)and patient gender(male/female),as well as the correlation among ocular(left/right),age,and radiographic stage(e.g.,international intraocular RB stage).Methods:The study enrolled 108 patients(127 eyes)with tumors confirmed by both surgical pathology and clinical diagnosis.These patients received treatment at the Orbital Disease and Ocular Oncology Department of Zhongshan Ophthalmic Center,Sun Yat-sen University(ZOC,SYSU)from May 2022 to December 2024.CT reconstruction and workstation segmentation techniques were used to delineate the eyeball,tumour,and calcification.A quantitative volumetric analysis method was applied,and statistical processing was conducted using R language(version 4.2.1).Comparisons were made across different genders(male/female),eye segmentation(left/right),age stratifications,and imaging stages.The t-test was applied to analyze the highest CT value,calcified regional volume(CRV),tumor volume(TV),eyeball volume(EV),CRV/EV ratio,TV/EV ratio,and CRV/TV ratio in these tumor patients.Results:There were statistically significant differences in EV between different gender groups(P<0.05).there were statistically significant differences in TV,CRV,EV,CRV/EV,and CRV/TV among different age groups(P<0.05).The highest CT values,TV,CRV,CRV/EV,and TV/EV also showed statistically significant differences among imaging stages(intraocular stage,glaucoma stage,extraocular stage)and lens position changes(position change,shape density change,no change)(P<0.05).Conclusions:In this group of tumor patients,the level of calcification deposition gradually increased as the disease progressed through the intraocular stage,glaucoma stage,and extraocular stage.Lens positional changes were associated with a gradual increase in the degree of calcification in patients with retinoblastoma(RB)as the disease advanced.关键词
视网膜母细胞瘤/钙化/计算机体层扫描Key words
retinoblastoma/calcify/computed tomography分类
医药卫生引用本文复制引用
郭丽旭,叶慧菁,聂时淮..视网膜母细胞瘤钙化容积CT影像特征和临床应用价值[J].眼科学报,2026,41(3):240-252,13.基金项目
广州市科学技术计划项目(SL2023A03J00480).This work was supported by Science and Technology Program of Guangzhou(SL2023A03J00480). （SL2023A03J00480）
