眼科学报2026，Vol.41Issue(3)：264-274,11.DOI:10.12419/25042303
铁死亡机制在糖尿病视网膜病变中的研究进展
Progress on the mechanisms of ferroptosis in diabetic retinopathy
潘艳超 1彭超1
作者信息
- 1. 广东医科大学江门市中心医院,江门 529000
- 折叠
摘要
Abstract
Ferroptosis represents an iron-dependent form of programmed cell death,marked by the abnormal accumulation of lipid peroxides and a disruption in redox homeostasis.It has been demonstrated to participate in the pathological process of fundus and metabolic diseases.Consequently,exploring its molecular mechanisms has emerged as a hotspot in translational medicine research.Recent research has revealed a close link between the development of diabetic retinopathy(DR)and ferroptosis.The pathological procession of DR encompasses iron metabolism disorders,a breakdown of antioxidant system,and a cascade of lipid peroxidation.This paper offers a comprehensive review of the molecular association between ferroptosis and the development of DR.It also elucidates the trigger pathways of ferroptosis in retinal cells under high-glucose conditions.Further in-depth analysis indicates that ferroptosis establishes a positive feedback loop with mitochondrial dysfunction and inflammation.Through the oxidative stress-inflammation-angiogenesis axis,it exacerbates the destruction of blood-retinal barrier and causes damage to the neurovascular unit.Moreover,this paper delves into the translational potential of intervention strategies targeting ferroptosis.It proposes that future research should prioritize the screening of stage-specific biomarkers and the analysis of dynamic regulatory networks.The ultimate goal is to provide a novel direction for further exploring the pathogenesis and prevention of DR.关键词
铁死亡/糖尿病视网膜病变/铁代谢/谷胱甘肽过氧化物酶4/铁死亡诱导剂/铁死亡抑制剂Key words
ferroptosis/diabetic retinopathy/iron metabolism/GPX4/ferroptosis inducer/ferroptosis inhibitor分类
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潘艳超,彭超..铁死亡机制在糖尿病视网膜病变中的研究进展[J].眼科学报,2026,41(3):264-274,11.
