眼科新进展2026，Vol.46Issue(4)：312-316,5.DOI:10.13389/j.cnki.rao.2026.0055
铁死亡对糖尿病视网膜病变视网膜神经血管单元组成细胞调控机制的研究进展
Research progress on the regulatory mechanisms of ferroptosis on the constit-uent cells of the retinal neurovascular unit in diabetic retinopathy
摘要
Abstract
Diabetic retinopathy(DR)is a common microvascular complication of diabetes,for which no definitive cure is currently available.Ferroptosis,a novel form of cell death characterized by iron dependency and lipid peroxidation,plays a prominent role in the retinal neurovascular unit.Emerging evidence indicates that ferroptosis affects the survival and func-tion of retinal endothelial cells,retinal pigment epithelial cells,pericytes,neurons,and glial cells,thereby contributing to hy-perglycemia-and aging-related retinal injury.Moreover,ferroptosis is closely associated with disruption of the blood-retinal barrier and retinal neurodegeneration.This review summarizes the molecular mechanisms of ferroptosis and its regulatory effects on the constituent cells of the retinal neurovascular unit in DR,providing a theoretical basis for the early diagnosis and intervention of DR.关键词
铁死亡/糖尿病视网膜病变/视网膜神经血管单元/细胞调控Key words
ferroptosis/diabetic retinopathy/retinal neurovascular unit/cell regulation分类
医药卫生引用本文复制引用
令娟,罗向霞,李嘉进,谢卓霖,雷迅文,康莉,杨芮,高英,胡亦明,王乾..铁死亡对糖尿病视网膜病变视网膜神经血管单元组成细胞调控机制的研究进展[J].眼科新进展,2026,46(4):312-316,5.基金项目
国家自然科学基金项目(编号:82360955) （编号:82360955）
甘肃省自然科学基金优秀博土生项目(编号:24JRRA614) （编号:24JRRA614）
甘肃省人民医院院内科研基金项目(编号:25GSSYB-9) （编号:25GSSYB-9）
甘肃省药品监督管理局科研项目(编号:2025GSMPA064) （编号:2025GSMPA064）
甘肃省卫生健康行业科研计划项目(编号:CSWSKY2022-44) （编号:CSWSKY2022-44）
甘肃省拔尖领军人才项目(省委人才小组发[2024]12号) （省委人才小组发[2024]12号）
甘肃省名中医罗向霞传承工作室建设项目 （）
