燕山大学学报2026，Vol.50Issue(2)：179-188,10.DOI:10.3969/j.issn.1007-791X.2026.02.009
光响应金-钯纳米酶体系构建及其类酶催化性能研究
Construction of light-responsive gold-palladium nanozyme system and its enzyme-like catalytic performance
摘要
Abstract
In this study,a gold-palladium nanozyme system based on polydopamine was constructed.This nanozyme system utilizes polydopamine,which has excellent biocompatibility and facile surface functionalization,as a carrier.Gold and palladium nanoparticles were loaded on its surface via an in-situ reduction method,thereby constructing a nanozyme system with high dispersion and stable structure.The as-prepared gold-palladium nanozyme exhibits multiple enzyme-mimetic activities,which are further enhanced under near infrared laser irradiation owing to the photothermal effect.Cell experiments demonstrated that under near-infrared laser irradiation,the gold-palladium nanozyme could significantly induce tumor cell apoptosis through the synergistic effect of photothermal therapy and catalytic generation of reactive oxygen species,while exhibiting favorable biocompatibility.This study constructed a multifunctional nanoplatform with photothermal-enhanced catalytic activity,providing an innovative strategy for effective tumor treatment.关键词
Au-Pd/纳米酶/光热/催化/肿瘤治疗Key words
Au-Pd/nanozyme/photothermal/catalysis/cancer therapy分类
化学化工引用本文复制引用
庞惠英,陈浩东,范瑢瑢,刘艳平..光响应金-钯纳米酶体系构建及其类酶催化性能研究[J].燕山大学学报,2026,50(2):179-188,10.基金项目
河北省高等学校科学技术研究项目(QN2023108) （QN2023108）
