现代中西医结合杂志2026，Vol.35Issue(3)：320-325,6.DOI:10.3969/j.issn.1008-8849.2026.03.005
化浊解毒养心方联合屈螺酮炔雌醇片(Ⅱ)治疗多囊卵巢综合征伴焦虑抑郁状态的临床研究
Efficacy of decoction for resolving turbidity,removing toxin and nourishing heart combined with drospirenone and ethinylestradiol tablets(Ⅱ)on polycystic ovary syndrome with anxiety and depression
摘要
Abstract
Objective It is to observe the clinical efficacy of decoction for resolving turbidity,removing toxin and nour-ishing heart combined with drospirenone and ethinylestradiol tablets(Ⅱ)in the treatment of polycystic ovary syndrome with anxiety and depression.Methods Sixty patients diagnosed as polycystic ovary syndrome with anxiety and depression at the gynecology clinic of Hebei Provincial Hospital of Traditional Chinese Medicine from December 2022 to December 2023 were selected and randomly divided into observation group and control group,with 30 cases in each group.The patients in the control group were orally treated with drospirenone and ethinylestradiol tablets(Ⅱ),and those in the observation group were orally treated with decoction for resolving turbidity,removing toxin and nourishing heart based on the therapy in the control group,both groups were treated for 3 menstrual cycles.The scores of traditional Chinese medicine syndrome,serum levels of sex hormones[luteinizing hormone(LH),follicle-stimulating hormone(FSH),testosterone(T),anti-Müllerian hormone(AMH),LH/FSH],glucose and lipid metabolism indicators[total cholesterol(TC),triglycerides(TG),fast-ing plasma glucose(FPG),fasting insulin(FINS),homeostasis model assessment of insulin resistance(HOMA-IR)],scores of the Self-Rating Anxiety Scale(SAS),Self-Rating Depression Scale(SDS)and modified polycystic ovary syn-drome health-related quality of life questionnaire(MPCOSQ)of patients in the two groups were compared before and after treatment.Results After treatment for 3 menstrual cycles,the overall effective rate in the observation group was significant-ly higher than that in the control group[90.0%(27/30)vs 76.7%(23/30),P<0.05].The traditional Chinese medi-cine syndrome scores,SAS and SDS scores of patients in the two groups were significantly lower after treatment than those before treatment(all P<0.05),and the scores in the observation group were significantly lower than those in the control group(all P<0.05);the sex hormone levels of patients in the two groups were improved significantly after treatment com-pared with before treatment(all P<0.05),and the levels of LH,T and AMH,as well as the LH/FSH ratio in the obser-vation group were significantly lower than those in the control group(all P<0.05);the levels of glucose and lipid metabo-lism indicators after treatment were significantly lower than those before treatment in the two groups(all P<0.05),and all indicators in the observation group were significantly lower than those in the control group(all P<0.05);the MPCOSQ scores after treatment were significantly higher than those before treatment(all P<0.05),and the scores in the observation group were significantly higher than those in the control group(P<0.05).Conclusion Decoction for resolving turbidity,removing toxin and nourishing heart combined with drospirenone and ethinylestradiol tablets(Ⅱ)can improve serum levels of hormone and glucose and lipid metabolism disorders,alleviate anxiety and depressive emotions and related traditional Chinese medicine syndromes and improve quality of life in patients with polycystic ovary syndrome with anxiety and depres-sion.关键词
多囊卵巢综合征/焦虑抑郁/化浊解毒养心方/心之浊毒/屈螺酮炔雌醇片(Ⅱ)/浊毒理论Key words
polycystic ovary syndrome/decoction for resolving turbidity,removing toxin and nourishing heart/turbidity and toxin of the heart/drospirenone and ethinylestradiol tablets(Ⅱ)/theory of turbidity and toxin分类
医药卫生引用本文复制引用
张珊,牛冰倩,陈慧娟..化浊解毒养心方联合屈螺酮炔雌醇片(Ⅱ)治疗多囊卵巢综合征伴焦虑抑郁状态的临床研究[J].现代中西医结合杂志,2026,35(3):320-325,6.基金项目
河北省中医药管理局科研计划项目(2021060) （2021060）
