中国肺癌杂志2026，Vol.29Issue(2)：131-140,10.DOI:10.3779/j.issn.1009-3419.2026.106.04
PYCR1在肿瘤发生发展中的作用和机制研究进展
Research Progress on the Role and Mechanisms of PYCR1 in Tumorigenesis and Progression
摘要
Abstract
Pyrroline-5-carboxylate reductase 1(PYCR1)is a key enzyme in the proline biosynthesis pathway and has garnered widespread attention in the field of tumor research in recent years.Studies have shown that PYCR1 is abnormally expressed in a variety of malignant tumors.It plays a significant role in tumorigenesis and development by participating in metabolic reprogramming of tumor cells,regulating key signaling pathways,influencing the tumor microenvironment,and me-diating immune evasion,among other mechanisms.This article systematically reviews the biological structure and functions of PYCR1,its expression characteristics in various tumors,and the underlying molecular mechanisms.The focus is on exploring its role in promoting the occurrence and development of different tumors,as well as its involvement in mediating chemother-apy resistance.Additionally,the research progress and clinical application prospects of PYCR1 as a potential therapeutic target are analyzed,providing a theoretical basis and research directions for the development of novel anti-tumor strategies.关键词
PYCR1/肿瘤代谢/信号通路/免疫调控/治疗靶点/脯氨酸合成Key words
Pyrroline-5-carboxylate reductase 1/Tumor metabolism/Signaling pathway/Immunoregulation/Therapeutic target/Proline synthesis引用本文复制引用
孟于琪,杨志昌,冯海明,李海天,李斌..PYCR1在肿瘤发生发展中的作用和机制研究进展[J].中国肺癌杂志,2026,29(2):131-140,10.基金项目
This paper was supported by the grants from the Medical Research Project of Gansu Province(No.GSWSQN2021-003,to Bin LI)and Natural Science Foundation of Gansu Province(No.24JRRA335,to Bin LI （No.GSWSQN2021-003,to Bin LI）
No.22JR5RA1011,to Yuqi MENG). 本文受甘肃省卫生健康行业科研计划项目(No.GSWSQN2021-003)和甘肃省自然科学基金项目(No.24JRRA335,No.22JR5RA1011)资助 （No.GSWSQN2021-003）
