中国临床药理学与治疗学2026，Vol.31Issue(3)：400-408,9.DOI:10.12092/j.issn.1009-2501.2026.03.012
肾上腺素不同给药途径治疗Ⅰ型超敏反应的研究进展
Research progress on the treatment of type Ⅰ hypersensitivity reactions via different epinephrine administration routes
摘要
Abstract
Epinephrine is the first-line drug for treating type I hypersensitivity reactions and can ef-fectively alleviate symptoms such as hypotension,erythema,urticaria,and angioedema,while also in-hibiting the further release of allergic mediators.In-tramuscular administration of epinephrine ensures rapid absorption and efficacy,and both epinephrine injection vials and auto-injectors are available on the market,providing timely treatment in emergen-cy situations.To enhance the convenience of drug administration and improve patient compliance,new routes of administration for epinephrine are being explored,including liquid nasal sprays,pow-der nasal sprays,sublingual formulations,and in-halers.This article summarizes the advantages and limitations of currently available and under-re-searched epinephrine formulations with different routes of administration and predicts future re-search directions and priorities.关键词
过敏反应/肾上腺素/给药途径/肌肉注射/黏膜给药Key words
anaphylaxis/epinephrine/routes of administration/intramuscular injection/mucosal administration分类
医药卫生引用本文复制引用
陈佳瑞,郑爱萍,张郃,张海利,程艺,刘春艳,李蒙,刘楠,王增明,张慧..肾上腺素不同给药途径治疗Ⅰ型超敏反应的研究进展[J].中国临床药理学与治疗学,2026,31(3):400-408,9.基金项目
国家重点研发计划资助项目(2023YFC2706100) （2023YFC2706100）
