中国计量大学学报2025，Vol.36Issue(4)：622-630,9.DOI:10.3969/j.issn.2096-2835.2025.04.014
表没食子儿茶素没食子酸酯与光甘草定协同作用抑制黑色素生成的研究
Study on the synergistic inhibition of melanin production by epigallocatechin-3-gallate and glabridin
摘要
Abstract
Aims:This paper aims to investigate the synergistic inhibitory effect of Epigallocatechin gallate(EGCG)and Glabridin(GLA)on melanin production.Methods:In vitro TYR activity inhibition and molecular docking were used to study the synergistic inhibition mechanism of EGCG and GLA on TY R.At the same time,the drug-containing spray was prepared;and the skin melanin production model of C57BL/6 mice induced by UVB was used to evaluate its whitening effect in vivo.Results:The combination index of EGCG and GLA was 0.87.The combination of EGCG with different active'pockets'on the surface of GLA and TYR proteins could significantly reduce skin melanin deposition and inhibit TYR expression.Conclusions:EGCG and GLA can effectively reduce melanin production by synergistically inhibiting TYR activity.关键词
表没食子儿茶素没食子酸酯/光甘草定/黑色素生成/协同抑制Key words
epigallocatechin-3-gallate/glabridin/melanin production/synergistic inhibition分类
医药卫生引用本文复制引用
陈昭闻,宋景鋈,徐维佳,雷轩灏,葛建..表没食子儿茶素没食子酸酯与光甘草定协同作用抑制黑色素生成的研究[J].中国计量大学学报,2025,36(4):622-630,9.基金项目
国家自然科学基金项目(No.31100499,31672394) （No.31100499,31672394）
