中国实验方剂学杂志2026，Vol.32Issue(9)：266-275,10.DOI:10.13422/j.cnki.syfjx.20251130
基于AMPK信号通路探讨中医药治疗结直肠癌的研究进展
Traditional Chinese Medicine Treatment of Colorectal Cancer Based on AMPK Signaling Pathway:A Review
摘要
Abstract
Colorectal cancer is a common malignant tumor of the digestive system.In recent years,its incidence rate and mortality are increasing year by year.Due to the complex pathogenesis and poor prognosis of patients,colorectal cancer poses a serious threat to human physical and mental health.Currently,although Western medicine treatment methods can to some extent inhibit tumor growth and alleviate patient symptoms,postoperative recurrence,metastasis,multiple adverse reactions,and susceptibility to drug resistance are prominent issues,resulting in unsatisfactory overall treatment outcomes.Therefore,exploring more efficient and safe treatment methods has become an urgent task.The adenosine monophosphate-activated protein kinase(AMPK)signaling pathway plays a regulatory role in the growth,differentiation,apoptosis,and autophagy of colorectal cancer cells,and is widely involved in the occurrence and development of colorectal cancer.It is considered an important target for colorectal cancer treatment.Traditional Chinese medicine has unique advantages in the treatment of colorectal cancer,as it can exert its effects through multiple mechanisms and pathways.It can prevent postoperative recurrence and metastasis,reduce adverse reactions to radiotherapy and chemotherapy,and improve patients'quality of life.It has become a key means of treating colorectal cancer.Research has shown that active ingredients in traditional Chinese medicine such as flavonoids,polyphenols,terpenes,and esters,as well as traditional Chinese medicine compounds such as Qingjie Fuzheng Granules and some traditional Chinese medicine extracts,have significant regulatory effects on AMPK and its interaction signaling pathways.They exert their anti-colorectal cancer effects by inducing autophagy and apoptosis in colorectal cancer cells,promoting ferroptosis,inhibiting epithelial-mesenchymal transition,reversing drug resistance,and arresting the cell cycle.This article reviewed and summarized the relevant research on traditional Chinese medicine in the treatment of colorectal cancer in recent years,with a focus on the mechanism of traditional Chinese medicine in regulating the AMPK signaling pathway for the treatment of colorectal cancer.It is expected to provide ideas and references for the development of new drugs for clinical anti-colorectal cancer treatment.关键词
腺苷酸活化蛋白激酶(AMPK)/信号通路/中医药/结直肠癌/研究进展Key words
adenosine monophosphate-activated protein kinase(AMPK)/signaling pathway/traditional Chinese medicine/colorectal cancer/research progress分类
医药卫生引用本文复制引用
胡洋,胡素芹,曾朔,罗磊,李明彦,张勤生..基于AMPK信号通路探讨中医药治疗结直肠癌的研究进展[J].中国实验方剂学杂志,2026,32(9):266-275,10.基金项目
国家自然科学基金项目(82305074) （82305074）
国家中医药管理局中国中医药科技发展中心联合研究项目(CXZH202304) （CXZH202304）
河南省中医药传承与创新人才工程(仲景工程)中医药学科领军人才项目(豫卫中医函[2021]08号) （仲景工程）
2022年度河南省重点研发与推广专项(科技攻关)支持项目(222102310240) （科技攻关）
河南省中医药科学研究专项(2023ZY2074) （2023ZY2074）
