中国实验方剂学杂志2026，Vol.32Issue(7)：84-92,9.DOI:10.13422/j.cnki.syfjx.20252324
基于中西医临床病证特点的慢性痛风性关节炎动物模型分析
Analysis of Chronic Gouty Arthritis Animal Models Based on Clinical Characteristics of Traditional Chinese and Western Medicine
摘要
Abstract
Objective:Based on the clinical characteristics of chronic gouty arthritis(CGA)in both traditional Chinese and western medicine,this study aims to systematically evaluate the clinical concordance of existing CGA animal models,providing recommendations for establishing animal models that align with the pathological characteristics of CGA and the manifestations of traditional Chinese medicine syndromes.Methods:By comprehensively retrieving Chinese and international databases such as China National Knowledge Infrastructure,Wanfang,VIP Chinese Science and Technology Periodical Database(VIP),and PubMed,all relevant literature on CGA animal models was collected.Based on the guidelines,the diagnostic criteria of both traditional Chinese and western medicine were summarized and organized.The evaluation indicators for the CGA model were constructed with reference to existing evaluation modes,and the CGA animal models were analyzed to systematically evaluate the clinical concordance of existing models.Results:The current methods used to construct CGA animal models mainly include monosodium urate crystal induction,high-protein diet induction(poultry lack urate oxidase),and high-fat diet combined with urate oxidase inhibitors and joint injection.Based on 11 pieces of included literature,the traditional Chinese and western medicine scoring data of each model were extracted,and the average scoring values of all models were ultimately calculated.The results show that the average clinical concordances of existing CGA animal models in both traditional Chinese and western medicine are 43.33％and 64.44％,respectively.Among them,the model with the highest clinical concordance rate is the one with a high-fat diet combined with potassium oxonate to induce hyperuricemia plus joint injection,achieving 83.33％clinical concordance in western medicine and 60％in traditional Chinese medicine.This model aligns well with the pathogenic characteristics and pathological changes of clinical CGA.Conclusion:Although current CGA animal models can simulate some pathological characteristics of CGA,they struggle to comprehensively reflect the complex pathological processes of CGA and the characteristics of traditional Chinese medicine syndromes.Therefore,in the future,it is necessary to establish the CGA animal models that incorporate the clinical disease and syndrome characteristics of traditional Chinese and western medicine and formulate the uniform model evaluation criteria,providing more precise tools for CGA mechanism research and the development of traditional Chinese medicine.关键词
慢性痛风性关节炎/动物模型/中西医结合/病证特点/临床吻合度分析Key words
chronic gouty arthritis/animal model/integration of traditional Chinese and Western medicine/characteristic of disease and syndrome/clinical concordance analysis分类
医药卫生引用本文复制引用
肖艳,郭洁梅,林巳塬,杨帆,陈强龙,陈小华,王美玲,张镇,罗家利,苏友新..基于中西医临床病证特点的慢性痛风性关节炎动物模型分析[J].中国实验方剂学杂志,2026,32(7):84-92,9.基金项目
国家自然科学基金项目(82474326) （82474326）
国家中医药管理局2021年岐黄学者支持项目(国中医药人教函[2022]6号) （国中医药人教函[2022]6号）
福建中医药大学苏友新岐黄学者传承工作室项目(闽中医[2023]56号) （闽中医[2023]56号）
