中国普通外科杂志2026，Vol.35Issue(2)：343-349,7.DOI:10.7659/j.issn.1005-6947.250598
常规血/尿生化指标与胰腺癌风险因果关联的孟德尔随机化分析
Routine blood and urine biochemical biomarkers in relation to pancreatic cancer risk:a Mendelian randomization analysis
贺逸嘉 1刘雍容 2张欣 3吴可柯4
作者信息
- 1. 中南大学湘雅三医院 肝胆外科,湖南 长沙 410013
- 2. 中南大学湘雅三医院 手术中心,湖南 长沙 410013
- 3. 湖南省湘潭市第二人民医院 消化内科,湖南 湘潭 411100
- 4. 中南大学湘雅三医院 麻醉科,湖南 长沙 410013
- 折叠
摘要
Abstract
Background and Aims:Early detection of pancreatic cancer(PC)remains challenging,and conventional biomarkers such as CA19-9 are inadequate for population screening.Routine blood and urine biochemical markers are widely accessible and reflect systemic physiological status;however,their causal relationships with PC risk remain unclear.Therefore,this study aimed to systematically evaluate the potential causal associations between 35 routine biochemical biomarkers and pancreatic cancer risk using a two-sample Mendelian randomization(MR)framework.
Methods:A two-sample MR study was conducted using genome-wide association study(GWAS)summary data from the UK Biobank for 35 biochemical traits.Outcome data for PC were obtained from the FinnGen consortium(release R12).The inverse-variance weighted(IVW)method was used as the primary analysis,complemented by MR-Egger,weighted median,and weighted mode approaches.Sensitivity analyses were performed to assess robustness.
Results:Two kidney function-related traits showed consistent causal associations with PC risk.Genetically predicted higher serum creatinine levels were associated with an 18%increased risk of PC per 1-standard deviation increment(OR=1.18,95%CI=1.03-1.36,P=0.019),whereas higher estimated glomerular filtration rate(eGFR)was associated with a 17%reduced risk(OR=0.83,95%CI=0.72-0.97,P=0.016).Sensitivity analyses supported the robustness of these findings,with no evidence of substantial heterogeneity or horizontal pleiotropy.
Conclusions:This MR study provides genetic evidence supporting a potential causal role of kidney function-related pathways in pancreatic cancer.Serum creatinine and eGFR may serve as promising host-related biomarkers for risk stratification and early detection,warranting further mechanistic and prospective validation.关键词
胰腺肿瘤/生物标记/肌酸酐/肾小球滤过率/孟德尔随机化分析Key words
Pancreatic Neoplasms/Biomarkers/Creatinine/Glomerular Filtration Rate/Mendelian Randomization Analysis分类
医药卫生引用本文复制引用
贺逸嘉,刘雍容,张欣,吴可柯..常规血/尿生化指标与胰腺癌风险因果关联的孟德尔随机化分析[J].中国普通外科杂志,2026,35(2):343-349,7.
