中国实验方剂学杂志2026，Vol.32Issue(7)：161-171,11.DOI:10.13422/j.cnki.syfjx.20252491
多囊卵巢综合征合并胰岛素抵抗的中西医整合策略:基于病机互补的协同增效机制探讨
Integrative Strategies of Traditional Chinese and Western Medicine for Polycystic Ovary Syndrome with Insulin Resistance:Synergistic Potentiation Mechanisms Based on Pathogenic Complementarity
摘要
Abstract
Polycystic ovary syndrome(PCOS)with insulin resistance(IR)represents a common complex endocrine-metabolic disorder in reproductive-aged women,posing substantial threats to their reproductive and long-term health.The networked characteristics of pathological mechanisms pose severe challenges in the diagnosis and treatment modes with a single medical system.Western medicine identifies it as a pathological axis with the core of"IR-hyperinsulinemia-hyperandrogenemia"and offers effective symptomatic treatments,it is often faced with limitations such as insufficient overall regulation and drug side effects.Traditional Chinese medicine is characterized by a holistic concept centered on the dysfunction of"kidney-spleen-liver"and syndrome differentiation and treatment,yet its microscopic action mechanisms remain to be fully elucidated.An integrative diagnosis and treatment mode of traditional Chinese medicine and western medicine provides a vital approach to overcoming these challenges.This review systematically sorted out the understanding of polycystic ovary syndrome with insulin resistance(PCOS-IR)pathogenesis from both Chinese and western medicine perspectives.An explainable mapping relation potentially existing between the molecular pathological networks defined by western medicine and the macroscopic dialectical system of traditional Chinese medicine was hypothesized.The synergistic potentiation mechanisms of integrative strategies of traditional Chinese medicine and western medicine were analyzed,with a focus on clarifying the recent progress of integrative diagnosis and treatment strategies.The paper aims to provide a more comprehensive and profound reference for research and clinical practice in this field,advance the further development of the prevention and treatment of PCOS-IR with integrated traditional Chinese medicine and western medicine,and explore the establishment of a more precise,individualized diagnosis and treatment system to make optimal clinical decisions.关键词
多囊卵巢综合征/胰岛素抵抗/中西医结合治疗/研究进展Key words
polycystic ovary syndrome/insulin resistance/integrative treatment of traditional Chinese and western medicine/research progress分类
医药卫生引用本文复制引用
汤如莹,刘恒昌,林龙飞,白栋汉,刘宇灵..多囊卵巢综合征合并胰岛素抵抗的中西医整合策略:基于病机互补的协同增效机制探讨[J].中国实验方剂学杂志,2026,32(7):161-171,11.基金项目
国家重点研发计划项目(2022YFC3501900) （2022YFC3501900）
中国中医科学院科技创新项目(CI2021A04301) （CI2021A04301）
