中国实验方剂学杂志2026，Vol.32Issue(7)：172-181,10.DOI:10.13422/j.cnki.syfjx.20251218
中药调控泪膜稳态缓解干眼的研究进展
Traditional Chinese Medicine Alleviates Dry Eye Disease by Regulating Tear Film Homeostasis:A Review
摘要
Abstract
Dry eye(DE)is a prevalent multifactorial disease of the ocular surface,clinically characterized by tear film homeostasis imbalance accompanied by related ocular surface symptoms.Specifically,the tear film is a thin liquid layer of tears covering the cornea and conjunctiva through blinking,while tear film homeostasis serves as the foundation for maintaining normal ocular surface structure and function.Insufficient tear secretion and excessive tear film evaporation lead to tear hyperosmolarity and the production of inflammatory mediators,disrupting tear film homeostasis and subsequently forming DE.Additionally,cascade reactions are triggered,resulting in a"vicious cycle of DE"that exacerbates the disease severity and prolongs its duration.Therefore,for DE treatment,it is crucial to restore tear film homeostasis and terminate this vicious cycle.Traditional Chinese medicine(TCM),which differentiates and treats DE based on systemic conditions,often achieves favorable therapeutic outcomes,offering additional treatment options for DE.Studies have demonstrated that TCM can alleviate DE by regulating tear film homeostasis and terminating the vicious cycle.This review systematically summarizes recent basic experimental research in China and abroad on TCM in alleviating DE by regulating tear film homeostasis,aiming to provide a theoretical basis for clinical treatment and an insight for research design.关键词
干眼/泪膜稳态失衡/中药/综述Key words
dry eye disease/tear film homeostasis imbalance/traditional Chinese medicine/review分类
医药卫生引用本文复制引用
田赛男,王彬安,陈瑶,刘桂成,唐丽,刘培,覃艮艳,彭俊,彭清华..中药调控泪膜稳态缓解干眼的研究进展[J].中国实验方剂学杂志,2026,32(7):172-181,10.基金项目
国家自然科学基金项目(81574031) （81574031）
湖南省人才托举工程—年青优秀科技人才培养计划项目(2023TJ-N25) （2023TJ-N25）
湖南省中医药科研计划项目(A2023001) （A2023001）
湖南中医药大学研究生创新课题项目(2024CX155) （2024CX155）
湖南省自然科学基金项目(2026JJ81071) （2026JJ81071）
