中国实用妇科与产科杂志2026，Vol.42Issue(3)：349-354,6.DOI:10.19538/j.fk2026030115
异体肾移植12例患者肾功能与子痫前期及妊娠结局的相关性分析
Correlation between renal function and preeclampsia/pregnancy outcomes in 12 pregnant recipients following allogeneic kidney transplantation
摘要
Abstract
Objective By analyzing changes in renal function before and during pregnancy in patients after allogeneic kidney transplantation,and their correlation with preeclampsia and pregnancy outcomes,this study aims to explore the impact of pre-pregnancy assessment and prenatal management on pregnancy outcomes.Methods Select 12 cases of pregnant patients after renal transplantation at the Obstetrics Department of the First Affiliated Hospital of Xi'an Jiaotong University between August 2020 and April 2024.Record data including interval from transplantation to pregnancy,use of immunosuppressive agents,renal function before and during pregnancy,obstetric complications,gestational age and mode of delivery,neonatal follow-up during hospitalization(neonatal weight,Apgar scores).Results The average interval from transplantation to pregnancy was 5.6 years(1.4-9.9 years).Three of the 10 patients who received tacrolimus-based immunosuppressants developed preeclampsia,while two of the two patients who received cyclosporine-based immunosuppressants developed preeclampsia.Five patients developed preeclampsia,and the incidence of fetal intrauterine growth restriction was significantly higher in the preeclampsia group than in the non-preeclampsia group(P=0.003),There was no significant difference in renal function between the two groups.There was no significant change in renal function before pregnancy compared to the early pregnancy period,but there were significant differences in serum creatinine,eGFR in the Mid-pregnancy period,and eGFR in the late pregnancy period compared to the pre-pregnancy period(P=0.02,P=0.02,P=0.03).Conclusions Close monitoring of renal function before and during pregnancy is essential.Pre-pregnancy and gestational serum creatinine and eGFR levels are closely associated with pregnancy outcomes.The transplanted kidney can undergo adaptive changes in response to pregnancy progression,though these adaptations may be limited compared to those of a native kidney.A multidisciplinary team's careful evaluation of the optimal timing for pregnancy before conception and strict blood pressure control during pregnancy are crucial for improving pregnancy outcomes.关键词
肾移植术后/肾功能变化/子痫前期/高危妊娠Key words
renal transplantation/alterations in renal function/preeclampsia/high-risk pregnancy分类
医药卫生引用本文复制引用
宋铭敏,付晶,刘哲,杨晓雨,李雪兰..异体肾移植12例患者肾功能与子痫前期及妊娠结局的相关性分析[J].中国实用妇科与产科杂志,2026,42(3):349-354,6.基金项目
国际科技合作计划项目一般项目(2022KW-22) International Science and Technology Cooperation Program-General Project(2022KW-22) （2022KW-22）
