中国实验方剂学杂志2026，Vol.32Issue(7)：276-281,6.DOI:10.13422/j.cnki.syfjx.20251440
基于"肠道菌群-肠-心轴"探讨溃疡性结肠炎与心房颤动的共病机制
Comorbidity Mechanism Between Ulcerative Colitis and Atrial Fibrillation Based on"Gut Microbiota-gut-heart"Axis
摘要
Abstract
The gut microbiota is regarded as the"eighth organ"of the human body and plays a critical regulatory role in the occurrence and progression of various diseases.Ulcerative colitis(UC)is a chronic inflammatory bowel disease with a complex etiology and a tendency toward recurrent episodes.In recent years,studies have shown that gut microbiota dysbiosis plays a key role in its pathological processes.Meanwhile,an increasing number of studies have demonstrated that imbalances in the gut microbiota and abnormalities in its metabolites are closely associated with the development of atrial fibrillation(AF).Although UC and AF belong to diseases of the digestive system and cardiovascular system,respectively,both exhibit systemic inflammatory characteristics and are often accompanied by gut microbiota dysregulation and abnormal metabolic products.However,systematic investigations into the mechanisms by which gut microbiota-derived metabolites act in these two diseases remain limited.Based on this,the present study adopts literature review and theoretical analysis methods,taking the"gut microbiota-gut-heart"axis as the entry point,to systematically summarize the signaling networks of three key classes of metabolites,i.e.,short-chain fatty acids(SCFAs),bile acids(BAs),and trimethylamine N-oxide(TMAO),in the comorbidity mechanism of UC and AF.The findings indicate that these metabolites may activate key inflammatory pathways,such as NF-κB and NLRP3,thereby synergistically mediating intestinal barrier dysfunction and systemic inflammation and constructing a potential comorbidity network.On this basis,potential intervention strategies for the treatment of UC-AF comorbidity,including probiotic intervention and fecal microbiota transplantation,are further discussed.This study aims to provide new theoretical evidence and research perspectives for prevention and treatment strategies of cross-system diseases.关键词
肠道菌群/肠道菌群代谢物/心房颤动/溃疡性结肠炎/粪菌移植Key words
gut microbiota/gut microbiota metabolites/atrial fibrillation/ulcerative colitis/fecal microbiota transplantation分类
医药卫生引用本文复制引用
冯美玉,张雯静,杜宜航,丁炫烨,胡元会,苑海涛..基于"肠道菌群-肠-心轴"探讨溃疡性结肠炎与心房颤动的共病机制[J].中国实验方剂学杂志,2026,32(7):276-281,6.基金项目
国家自然科学基金项目(82074409) （82074409）
首都卫生发展科研专项(首发2022-1-4153) （首发2022-1-4153）
中国中医科学院科技创新工程-重大攻关项目(CI2021A00918) （CI2021A00918）
