中国药理学通报2026，Vol.42Issue(3)：406-410,5.DOI:10.12360/CPB202510011
不同应激下高尔基体自噬的机制及关联研究
Mechanisms of Golgiphagy and their correlations under different stresses
摘要
Abstract
Golgiphagy,a newly identified selective autophagy pathway,mediates the direct degradation of Golgi components to maintain its structural and functional homeostasis.It serves as a pivotal mechanism in the cellular response to environmental stress and has emerged as a frontier hotspot in cell biology and disease research.Since its initial discovery and naming in 2020,significant breakthroughs have been achieved in the de-velopment of research tools,elucidation of core molecular mechanisms,and exploration of disease associations.This ar-ticle systematically reviews the induction mechanisms of Gol-giphagy under both nutritional and non-nutritional stress condi-tions,elaborates on the compartmentalized,multi-receptor co-operative regulatory network centered around various receptors,and discusses its interplay with other organelles as well as its roles in various diseases.Finally,the challenges and future di-rections in this field are outlined,aiming to facilitate the transla-tion of fundamental research on Golgiphagy toward clinical ap-plications in Golgi medicine.关键词
高尔基体自噬/高尔基体应激/高尔基体医学/跨膜9超家族成员3/高尔基体磷蛋白3/自噬相关蛋白8aKey words
Golgiphagy/Golgi apparatus stress/Golgi appara-tus medicine/transmembrane 9 superfamily member 3/Golgi phosphoprotein 3/autophagy-related protein 8a分类
医药卫生引用本文复制引用
刘赞,王姝之,肖凌,陈临溪..不同应激下高尔基体自噬的机制及关联研究[J].中国药理学通报,2026,42(3):406-410,5.基金项目
国家自然科学基金资助项目(No 81973326) （No 81973326）
湖南省自然科学基金资助项目(No 2024JJ7571) （No 2024JJ7571）
