中国药理学通报2026，Vol.42Issue(3)：415-422,8.DOI:10.12360/CPB202510067
基于多组学技术和网络药理学探讨雷公藤制剂生殖毒性减毒增效的研究进展
Research progress on attenuating toxicity and enhancing efficiency of Tripterygium wilfordii preparations against reproductive toxicity based on multi-omics technology and network pharmacology
摘要
Abstract
Tripterygium wilfordii preparation has a significant effect in the treatment of autoimmune diseases such as rheuma-toid arthritis and systemic lupus erythematosus,but its repro-ductive toxicity greatly limits its clinical application.Multi-omics technologies(genomics,transcriptomics,proteomics,metabolomics)can systematically analyze the mechanism of re-productive toxicity at the molecular level,and network pharma-cology can construct a regulatory network of'toxic components-core targets-key pathways'.The combination of the two provides a new way to clarify the mechanism of reproductive toxicity of Tripterygium wilfordii and to study the strategy of reducing toxic-ity and increasing efficiency.This paper systematically reviews the material basis and mechanism of reproductive toxicity of Tripterygium wilfordii,and focuses on the application progress of multi-omics technology and network pharmacology in the mechanism analysis of reproductive toxicity of Tripterygium wil-fordii and the strategy of reducing toxicity and increasing effi-ciency,aiming to provide reference for the clinical safe use of Tripterygium wilfordii preparations and the development of new low-toxic preparations.关键词
雷公藤/生殖毒性/减毒增效/多组学技术/网络药理学/机制研究Key words
Tripterygium wilfordii/reproductive toxicity/re-ducing toxicity and increasing efficiency/multi-omics technol-ogy/network pharmacology/mechanism research分类
医药卫生引用本文复制引用
郑肖庆,徐闪闪,王龙,韩姗姗,邢亚萍,丁樱..基于多组学技术和网络药理学探讨雷公藤制剂生殖毒性减毒增效的研究进展[J].中国药理学通报,2026,42(3):415-422,8.基金项目
国家自然科学基金青年基金资助项目(No 82305311,82305310) （No 82305311,82305310）
河南省自然科学基金资助项目(No 242102311265) （No 242102311265）
河南省中医药科学研究专项课题(No 2023ZY2044) （No 2023ZY2044）
